Persistent cytarabine and daunorubicin exposure after administration of novel liposomal formulation CPX-351: population pharmacokinetic assessment
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DOI: 10.1007/s00280-017-3484-5
Abstract: PurposeCPX-351 is a novel liposomal formulation of cytarabine and daunorubicin which has recently been FDA approved for treatment of acute myeloid leukemia (AML). The current study investigated the pharmacokinetics (PK) of this liposomal formulation.MethodsCPX-351 PK… read more here.
Keywords: liposomal formulation; cytarabine; pharmacology; cytarabine daunorubicin ... See more keywords
A novel osmoprotective liposomal formulation from synthetic phospholipids to reduce in vitro hyperosmolar stress in dry eye treatments.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of liposome research"
DOI: 10.1080/08982104.2022.2087083
Abstract: Dry eye disease (DED) is a worldwide, multifactorial disease mainly caused by a deficit in tear production or increased tear evaporation with an increase in tear osmolarity and inflammation. This causes discomfort and there is… read more here.
Keywords: synthetic phospholipids; formulation synthetic; stress; liposomal formulation ... See more keywords
Dog-specific hemorrhagic changes induced by liposomal formulations, in the liver and the gallbladder
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Toxicologic Pathology"
DOI: 10.1293/tox.2019-0029
Abstract: Although several liposomal drugs, including liposomal doxorubicin, have been approved, the etiology of the pathological responses caused by their physicochemical properties remains unknown. Herein, we investigated the pathological changes in the liver and the gallbladder… read more here.
Keywords: liposomal formulation; hemorrhagic changes; liver gallbladder; doxorubicin ... See more keywords
Development of a stable single-vial liposomal formulation for vincristine
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DOI: 10.2147/ijn.s205276
Abstract: Background: Vincristine is a potent therapeutic agent with well-defined activity against hematologic malignancies and solid tumors. It is a cell-cycle specific drug with concentration and exposure duration dependent activity. When used by liposomal delivery, it… read more here.
Keywords: liposomal formulation; formulation; development stable; drug ... See more keywords
Liposomal Formulation Improves the Bioactivity of Usnic Acid in RAW 264.7 Macrophage Cells Reducing its Toxicity.
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DOI: 10.2174/1567201820666230111112415
Abstract: BACKGROUND Reactive oxygen species (ROS) production and oxidative stress may be responsible for the onset of several chronic diseases. Usnic acid (UA) is a natural secondary metabolite of lichens with several healthful bioactivities, including antioxidant… read more here.
Keywords: liposomal formulation; solubility; toxicity; usnic acid ... See more keywords
A Liposomal Formulation to Exploit the Bioactive Potential of an Extract from Graciano Grape Pomace
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DOI: 10.3390/antiox11071270
Abstract: Antioxidant compounds with health benefits can be found in food processing residues, such as grape pomace. In this study, antioxidants were identified and quantified in an extract obtained from Graciano red grape pomace via a… read more here.
Keywords: potential extract; extract; liposomal formulation; grape pomace ... See more keywords
Characterization of a Mesoporous Silica Nanoparticle Formulation Loaded with Mitomycin C Lipidic Prodrug (MLP) and In Vitro Comparison with a Clinical-Stage Liposomal Formulation of MLP
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14071483
Abstract: Nanomedicines have revolutionized the treatment of certain types of cancer, as is the case of doxil, liposomal formulation with doxorubicin encapsulated, in the treatment of certain types of ovarian cancer, AIDS-related Kaposi sarcoma, and multiple… read more here.
Keywords: liposomal formulation; formulation; mesoporous silica; prodrug ... See more keywords
Novel Liposomal Formulation of Baicalein for the Treatment of Pancreatic Ductal Adenocarcinoma: Design, Characterization, and Evaluation
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DOI: 10.3390/pharmaceutics15010179
Abstract: Pancreatic cancer (PC) is one of the deadliest cancers so there is an urgent need to develop new drugs and therapies to treat it. Liposome-based formulations of naturally-derived bioactive compounds are promising anticancer candidates due… read more here.
Keywords: liposomal formulation; formulation; ductal adenocarcinoma; pancreatic ductal ... See more keywords
Liposomal Formulation of ChimeraT, a Multiple T-Cell Epitope-Containing Recombinant Protein, Is a Candidate Vaccine for Human Visceral Leishmaniasis
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DOI: 10.3390/vaccines8020289
Abstract: Background: Leishmaniases are neglected diseases caused by infection with Leishmania parasites and there are no human vaccines in use routinely. The purpose of this study was to examine the immunogenicity of ChimeraT, a novel synthetic… read more here.
Keywords: liposomal formulation; visceral leishmaniasis; chimerat; formulation chimerat ... See more keywords
Characterization, purity assessment, and preparation of liposomal formulation of 2,4,6-trihydroxygeranylacetophenone
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DOI: 10.4314/tjpr.v19i10.1
Abstract: Purpose: To prepare, characterize, and determine the purity of 2,4,6-trihydroxygeranylacetophenone (tHGA), and also to develop and characterize a liposomal formulation of tHGA to overcome its poor water solubility. Methods: The tHGA was synthesized and then… read more here.
Keywords: liposomal formulation; formulation; purity; characterization ... See more keywords