Optimization of liposomal topotecan for use in treating neuroblastoma
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Medicine"
DOI: 10.1002/cam4.1083
Abstract: The purpose of this work was to develop an optimized liposomal formulation of topotecan for use in the treatment of patients with neuroblastoma. Drug exposure time studies were used to determine that topotecan (Hycamtin) exhibited… read more here.
Keywords: topotecan use; formulation; drug; liposomal topotecan ... See more keywords
Abstract 2699: FF-10850, a dihydrosphingomyelin (DHSM)-based novel liposomal topotecan, achieved favorable efficacy and safety in combination with platinum, PARP and immune checkpoint inhibitors
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2699
Abstract: Introduction: Topotecan is approved as a monotherapy for ovarian and small cell lung cancers. Although topotecan is also approved in combination with cisplatin for cervical cancer, reductions of dose and administration frequency are required due… read more here.
Keywords: safety; combination; efficacy; liposomal topotecan ... See more keywords