Engineering of Saposin C Protein Chimeras for Enhanced Cytotoxicity and Optimized Liposome Binding Capability
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DOI: 10.3390/pharmaceutics13040583
Abstract: Saposin C (sapC) is a lysosomal, peripheral-membrane protein displaying liposome fusogenic capabilities. Proteoliposomes of sapC and phosphatidylserine have been shown to be toxic for cancer cells and are currently on clinical trial to treat glioblastoma.… read more here.
Keywords: protein; engineering; saposin; liposome binding ... See more keywords