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   Articles with "lipotoxicity" as a keyword



Lipotoxicity induces hepatic protein inclusions through TANK binding kinase 1–mediated p62/sequestosome 1 phosphorylation

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recommendations! Published in 2018 at "Hepatology"

DOI: 10.1002/hep.29742

Abstract: Obesity commonly leads to hepatic steatosis, which often provokes lipotoxic injuries to hepatocytes that cause nonalcoholic steatohepatitis (NASH). NASH, in turn, is associated with the accumulation of insoluble protein aggregates that are composed of ubiquitinated… read more here.

Keywords: protein; lipotoxicity; p62; p62 sequestosome ... See more keywords
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What Is Lipotoxicity?

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recommendations! Published in 2017 at "Advances in experimental medicine and biology"

DOI: 10.1007/978-3-319-48382-5_8

Abstract: Enlarged fat cells in obese adipose tissue diminish capacity to store fat and are resistant to the anti-lipolytic effect of insulin. Insulin resistance (IR)-associated S-nitrosylation of insulin-signaling proteins increases in obesity. In accordance with the… read more here.

Keywords: lipotoxicity; insulin; fatty acids; biology ... See more keywords

GCN5L1 controls renal lipotoxicity through regulating acetylation of fatty acid oxidation enzymes

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recommendations! Published in 2019 at "Journal of Physiology and Biochemistry"

DOI: 10.1007/s13105-019-00711-6

Abstract: Dyslipidemia is a common risk factor of chronic kidney disease (CKD). Current notion suggests that insufficient intracellular fatty acid oxidation (FAO) and subsequently enhanced fatty acid esterification within renal resident cells, a process termed as… read more here.

Keywords: acetylation; lipotoxicity; fatty acid; renal lipotoxicity ... See more keywords

Canagliflozin attenuates lipotoxicity in cardiomyocytes and protects diabetic mouse hearts by inhibiting the mTOR/HIF-1α pathway

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recommendations! Published in 2021 at "iScience"

DOI: 10.1016/j.isci.2021.102521

Abstract: Summary Lipotoxicity plays an important role in the development of diabetic heart failure (HF). Canagliflozin (CAN), a marketed sodium-glucose co-transporter 2 inhibitor, has significantly beneficial effects on HF. In this study, we evaluated the protective… read more here.

Keywords: lipotoxicity cardiomyocytes; hif pathway; lipotoxicity; mtor hif ... See more keywords

Mitochondria-Dependent Oxidative Stress Mediates ZnO Nanoparticle (ZnO NP)-Induced Mitophagy and Lipotoxicity in Freshwater Teleost Fish.

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recommendations! Published in 2022 at "Environmental science & technology"

DOI: 10.1021/acs.est.1c07198

Abstract: Due to many special characteristics, zinc oxide nanoparticles (ZnO NPs) are widely used all over the world, leading to their wide distribution in the environment. However, the toxicities and mechanisms of environmental ZnO NP-induced changes… read more here.

Keywords: oxidative stress; zno induced; mitophagy; zno ... See more keywords

Sirt3-Sod2-mROS-Mediated Manganese Triggered Hepatic Mitochondrial Dysfunction and Lipotoxicity in a Freshwater Teleost.

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recommendations! Published in 2022 at "Environmental science & technology"

DOI: 10.1021/acs.est.2c00585

Abstract: Exposure to excessive manganese (Mn) is toxic to humans and animals. However, the toxic effects and mechanisms of excessive Mn influencing the vertebrates have been highly overlooked. In the present study, dietary Mn overload significantly… read more here.

Keywords: sirt3; oxidative stress; mitochondrial dysfunction; sod2 ... See more keywords

Co-Exposure to Different Zinc Concentrations and High-Fat Diet Modules Endoplasmic Reticulum Stress and Lipotoxicity through the MTF-1/GPx7 Axis in Yellow Catfish (Pelteobagrus fulvidraco).

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recommendations! Published in 2025 at "Journal of agricultural and food chemistry"

DOI: 10.1021/acs.jafc.4c11635

Abstract: As industrialization and societal development accelerate, various organisms, including humans, are exposed to environmental hazards, such as zinc (Zn) and high-fat diet (HFD). These widespread exposures pose significant threats to public health; however, the combined… read more here.

Keywords: mtf gpx7; stress; high fat; lipotoxicity ... See more keywords
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Exploiting lipotoxicity for the treatment of liver cancer.

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recommendations! Published in 2021 at "British journal of cancer"

DOI: 10.1038/s41416-021-01479-7

Abstract: Metabolic alterations occur frequently in solid tumours, but metabolic cancer therapies are limited by the complexity and plasticity of metabolic networks. We could recently show that activation of the liver X receptor alpha (LXRα) and… read more here.

Keywords: cancer; lipotoxicity; treatment liver; cancer exploiting ... See more keywords

The downregulation of SCGN induced by lipotoxicity promotes NLRP3-mediated β-cell pyroptosis

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recommendations! Published in 2024 at "Cell Death Discovery"

DOI: 10.1038/s41420-024-02107-y

Abstract: Lipotoxicity is a well-established phenomenon that could exacerbate damage to islet β-cells and play a significant role in the development of type 2 diabetes, the underlying mechanisms of which, however, remain unclear. In lipotoxic conditions,… read more here.

Keywords: induced lipotoxicity; lipotoxicity; cell; scgn ... See more keywords
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Progesterone receptor membrane component 1 reduces cardiac steatosis and lipotoxicity via activation of fatty acid oxidation and mitochondrial respiration

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recommendations! Published in 2021 at "Scientific Reports"

DOI: 10.1038/s41598-021-88251-2

Abstract: Obesity is implicated in cardiovascular disease and heart failure. When fatty acids are transported to and not adequately oxidized in cardiac cells, they accumulate, causing lipotoxicity in the heart. Since hepatic progesterone receptor membrane component… read more here.

Keywords: pgrmc1; heart; pgrmc1 mice; lipotoxicity ... See more keywords

Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity

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recommendations! Published in 2019 at "Autophagy"

DOI: 10.1080/15548627.2019.1598751

Abstract: ABSTRACT Saturated fatty acid (SFA)-induced lipotoxicity is caused by the accumulation of reactive oxygen species (ROS), which is associated with damaged mitochondria. Moreover, lipotoxicity is crucial for the progression of nonalcoholic steatohepatitis (NASH). Autophagy is… read more here.

Keywords: protein; lipotoxicity; kinase; ulk1 unc ... See more keywords