Canagliflozin attenuates lipotoxicity in cardiomyocytes and protects diabetic mouse hearts by inhibiting the mTOR/HIF-1α pathway
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DOI: 10.1016/j.isci.2021.102521
Abstract: Summary Lipotoxicity plays an important role in the development of diabetic heart failure (HF). Canagliflozin (CAN), a marketed sodium-glucose co-transporter 2 inhibitor, has significantly beneficial effects on HF. In this study, we evaluated the protective… read more here.
Keywords: lipotoxicity cardiomyocytes; hif pathway; lipotoxicity; mtor hif ... See more keywords