Allylphenols as a new class of human 15‐lipoxygenase‐1 inhibitors
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DOI: 10.1002/ddr.21749
Abstract: In this study, a series of mono‐ and diallylphenol derivative were designed, synthesized, and evaluated as potential human 15‐lipoxygenase‐1 (15‐hLOX‐1) inhibitors. Radical scavenging potency of the synthetic allylphenol derivatives was assessed and the results were… read more here.
Keywords: lipoxygenase; new class; class human; human lipoxygenase ... See more keywords
Bioprospection of anti‐inflammatory phytochemicals suggests rutaecarpine and quinine as promising 15‐lipoxygenase inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28634
Abstract: 15‐Lipoxygenase (15‐LOX) belongs to the family of nonheme iron containing enzymes that catalyzes the peroxidation of polyunsaturated fatty acids (PUFAs) to generate eicosanoids that play an important role in signaling pathways. The role of 15‐LOX… read more here.
Keywords: anti inflammatory; lipoxygenase; rut; rutaecarpine quinine ... See more keywords
Functional characterization of a novel arachidonic acid 12S‐lipoxygenase in the halotolerant bacterium Myxococcus fulvus exhibiting complex social living patterns
Sign Up to like & getrecommendations! Published in 2018 at "MicrobiologyOpen"
DOI: 10.1002/mbo3.775
Abstract: Lipoxygenases are lipid peroxidizing enzymes, which frequently occur in higher plants and mammals. These enzymes are also expressed in lower multicellular organisms but here they are not widely distributed. In bacteria, lipoxygenases rarely occur and… read more here.
Keywords: lipoxygenase; arachidonic acid; functional characterization; myxococcus fulvus ... See more keywords
Red-kerneled rice proanthocyanidin inhibits arachidonate 5-lipoxygenase and decreases psoriasis-like skin inflammation.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2020.108307
Abstract: 5-lipoxygenase is a key enzyme in the synthesis of leukotrienes from arachidonic acid. The produced leukotrienes are involved in inflammatory diseases including psoriasis, asthma, and atherosclerosis. A suitable 5-lipoxygenase inhibitor might be useful for preventing… read more here.
Keywords: lipoxygenase; proanthocyanidin; kerneled rice; psoriasis ... See more keywords
Synthesis of 13R,20-dihydroxy-docosahexaenoic acid by site-directed mutagenesis of lipoxygenase derived from Oscillatoria nigro-viridis PCC 7112.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.09.079
Abstract: Lipoxygenases (LOXs) are implicated in the biosynthesis of pro- and anti-inflammatory lipid mediators involved in immune cell signaling, most of which catalyze peroxidation of polyunsaturated fatty acids by distinct regio- and stereoselectivity. Current reports suggested… read more here.
Keywords: lipoxygenase; 13r dihydroxy; docosahexaenoic acid; dihydroxy docosahexaenoic ... See more keywords
The mediation of central cyclooxygenase and lipoxygenase pathways in orexin-induced cardiovascular effects
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DOI: 10.1016/j.brainres.2020.147239
Abstract: Previously it was reported that central orexin (OX) and arachidonic acid (AA) signaling pathways played an active role in the control of the cardiovascular system. It was also reported that they have exhibited their cardiovascular… read more here.
Keywords: lipoxygenase; central cyclooxygenase; mediation central; induced cardiovascular ... See more keywords
12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat.
Sign Up to like & getrecommendations! Published in 2019 at "Cell metabolism"
DOI: 10.1016/j.cmet.2019.07.001
Abstract: Distinct oxygenases and their oxylipin products have been shown to participate in thermogenesis by mediating physiological adaptations required to sustain body temperature. Since the role of the lipoxygenase (LOX) family in cold adaptation remains elusive,… read more here.
Keywords: lipoxygenase; metabolism; cold adaptation; glucose metabolism ... See more keywords
Thyme essential oils from Spain: Aromatic profile ascertained by GC-MS, and their antioxidant, anti-lipoxygenase and antimicrobial activities.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of food and drug analysis"
DOI: 10.1016/j.jfda.2017.05.004
Abstract: Six samples of red thyme (Thymus zygis) and two samples of winter thyme (Thymus hyemalis) essential oils (EOs) were obtained from plants cultivated in south-eastern Spain and extracted by steam distillation. Analysis by gas chromatography… read more here.
Keywords: lipoxygenase; spain aromatic; aromatic profile; oils spain ... See more keywords
12/15 lipoxygenase: A crucial enzyme in diverse types of cell death
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2018.04.002
Abstract: The 12/15-lipoxygenase (12/15-LOX) enzymes react with polyunsaturated fatty acids producing active lipid metabolites that are involved in plethora of human diseases including neurological disorders. A great many of elegant studies over the last decades have… read more here.
Keywords: lipoxygenase; crucial enzyme; cell death; lipoxygenase crucial ... See more keywords
Anti-inflammatory pregnane-type steroid derivatives clathroids A-B from the marine Microcionidae sponge Clathria (Thalysias) vulpina: Prospective duel inhibitors of pro-inflammatory cyclooxygenase-2 and 5-lipoxygenase
Sign Up to like & getrecommendations! Published in 2021 at "Steroids"
DOI: 10.1016/j.steroids.2021.108858
Abstract: Two pregnane-type of steroid derivatives characterized as 5α-pregna-3β-methyl pent-3-enoate-12β, 16β diol-20-one (clathroid A) and 12β,15β- dihydroxypregna-4,6-diene-3,20-dione (clathroid B) were purified from the crude extract of the marine sponge, Clathria (Thalysias) vulpina (family Microcionidae) by extensive… read more here.
Keywords: anti inflammatory; lipoxygenase; thalysias vulpina; cyclooxygenase ... See more keywords
In Vitro Biosynthetic Pathway Investigations of Neuroprotectin D1 (NPD1) and Protectin DX (PDX) by Human 12-Lipoxygenase, 15-Lipoxygenase-1, and 15-Lipoxygenase-2.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry"
DOI: 10.1021/acs.biochem.0c00931
Abstract: In this paper, human platelet 12-lipoxygenase [h12-LOX (ALOX12)], human reticulocyte 15-lipoxygenase-1 [h15-LOX-1 (ALOX15)], and human epithelial 15-lipoxygenase-2 [h15-LOX-2 (ALOX15B)] were observed to react with docosahexaenoic acid (DHA) and produce 17S-hydroperoxy-4Z,7Z,10Z,13Z,15E,19Z-docosahexaenoic acid (17S-HpDHA). The kcat/KM values… read more here.
Keywords: lipoxygenase; 17s hpdha; h15 lox;