New Hydroxycinnamic Acid Esters as Novel 5-Lipoxygenase Inhibitors That Affect Leukotriene Biosynthesis
Sign Up to like & getrecommendations! Published in 2017 at "Mediators of Inflammation"
DOI: 10.1155/2017/6904634
Abstract: Leukotrienes are inflammatory mediators that actively participate in the inflammatory response and host defense against pathogens. However, leukotrienes also participate in chronic inflammatory diseases. 5-lipoxygenase is a key enzyme in the biosynthesis of leukotrienes and… read more here.
Keywords: biosynthesis; acid esters; lipoxygenase inhibitor; hydroxycinnamic acid ... See more keywords
Itraconazole Increases Resolvin E3 Concentration and 12/15-lipoxygenase Inhibitor Attenuates Itraconazole Cytotoxicity in Cervical Cancer Cells
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DOI: 10.21873/anticanres.15231
Abstract: Background/Aim: The anticancer mechanism of itraconazole remains unsolved; therefore, we studied itraconazole-induced alterations in specialized pro-resolving mediators (SPMs) in cancer cells. Materials and Methods: The human cervical squamous carcinoma cell line CaSki was cultured with… read more here.
Keywords: lipoxygenase inhibitor; itraconazole increases; cancer cells;