Development and Optimization of a High-Throughput Screening Assay for Rapid Evaluation of Lipstatin Production by Streptomyces Strains
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DOI: 10.1007/s00284-017-1420-x
Abstract: Pancreatic lipase inhibitors, such as tetrahydrolipstatin (orlistat), are used in anti-obesity treatments. Orlistat is the only anti-obesity drug approved by the European Medicines Agency (EMA). The drug is synthesized by saturation of lipstatin, a β-lactone… read more here.
Keywords: lipstatin; lipstatin production; pancreatic lipase; lipase ... See more keywords