Liquiritin alleviates alpha‐naphthylisothiocyanate‐induced intrahepatic cholestasis through the Sirt1/FXR/Nrf2 pathway
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DOI: 10.1002/jat.4385
Abstract: Liquiritin (LQ) is an important monomer active component in flavonoids of licorice. The objective of this study was to evaluate the hepatoprotective effects of LQ in cholestatic mice. LQ (40 or 80 mg/kg) was intragastrically administered… read more here.
Keywords: liquiritin; fxr nrf2; sirt1 fxr; expression ... See more keywords
Probing the vibrational spectroscopic properties and binding mechanism of anti-influenza agent Liquiritin using experimental and computational studies
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DOI: 10.1007/s11164-020-04216-6
Abstract: Liquiritin is an anti-viral agent of H1N1 and H3N2 influenza A virus which was reported to inhibit H1N1 and H3N2 NA enzyme with IC50 value of 82.3 and > 100 μM, respectively. The ground state optimized… read more here.
Keywords: h1n1 h3n2; vibrational spectroscopic; spectroscopic properties; properties binding ... See more keywords
Liquiritigenin and liquiritin alleviated monocrotaline-induced hepatic sinusoidal obstruction syndrome via inhibiting HSP60-induced inflammatory injury.
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DOI: 10.1016/j.tox.2019.152307
Abstract: Hepatic sinusoidal obstruction syndrome (HSOS) is a life-threatening liver disease caused by the damage to liver sinusoidal endothelial cells (LSECs). Liquiritigenin and liquiritin are two main compounds in Glycyrrhizae Radix et Rhizoma (Gan-cao). Our previous… read more here.
Keywords: liquiritin alleviated; mct induced; liquiritigenin liquiritin; liquiritin ... See more keywords
Protective effect of liquiritin on coronary heart disease through regulating the proliferation of human vascular smooth muscle cells via upregulation of sirtuin1
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DOI: 10.1080/21655979.2021.2024687
Abstract: ABSTRACT This study aimed to explore whether liquiritin affects the development of coronary heart disease by regulating the proliferation and migration of human vascular smooth muscle cells (hVSMCs). A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2 H-tetrazolium bromide (MTT) assay and… read more here.
Keywords: cell; liquiritin; proliferation; coronary heart ... See more keywords
Liquiritin inhibits H2 O2 -induced oxidative stress injury in H9c2 cells via the AMPK/SIRT1/NF-κB signaling pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of food biochemistry"
DOI: 10.1111/jfbc.14351
Abstract: Heart failure (HF) is a serious disease with high mortality. Oxidative stress plays a vital role in its occurrence and development. Licorice is commonly used to treat HF in traditional Chinese medicine. Liquiritin, the main… read more here.
Keywords: stress; liquiritin; oxidative stress; h9c2 ... See more keywords