Lirilumab and Avelumab Enhance Anti-HPV+ Cervical Cancer Activity of Natural Killer Cells via Vav1-Dependent NF-κB Disinhibition
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DOI: 10.3389/fonc.2022.747482
Abstract: Background We investigated the efficacy and mechanism of the anti-KIR immunotherapy lirilumab and anti-PD-L1 immunotherapy avelumab on natural killer (NK) cell activity against HPV+ cervical cancer. Methods NK cell-mediated lysis of autologous biopsy-derived malignant cervical… read more here.
Keywords: cervical cancer; cell; disinhibition; hpv cervical ... See more keywords