Phenylephrine alleviates 131I damage in submandibular gland through promoting endogenous stem cell regeneration via lissencephaly-1 upregulation.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2020.114999
Abstract: Thyroid cancer is the most common endocrine malignancy. 131I ablation therapy is an effective treatment for patients with differentiated thyroid cancer (DTC) but frequently causes radiation damage in salivary glands (SGs). Stem cell-based regenerative therapy… read more here.
Keywords: cell regeneration; endogenous stem; stem cell; lis1 ... See more keywords
Abstract P2-04-05: The dynein regulator LIS1 maintains cell cycle progression and DNA integrity in TNBC, and can be targeted to improve paclitaxel response
Sign Up to like & getrecommendations! Published in 2025 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.sabcs24-p2-04-05
Abstract: Triple-negative breast cancer (TNBC) is a highly aggressive disease that typically exhibits faster growth and higher metastatic spread than other subtypes. There is a paucity of treatments available for TNBC, further contributing to poor patient… read more here.
Keywords: cancer; paclitaxel; cell cycle; progression ... See more keywords
MiR-380 inhibits the proliferation and invasion of cholangiocarcinoma cells by silencing LIS1
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Cell International"
DOI: 10.1186/s12935-024-03241-4
Abstract: The objective of this study was to determine the role and regulatory mechanism of miR-380 in cholangiocarcinoma. The TargetScan database and a dual-luciferase reporter assay system were used to determine if LIS1 was a target… read more here.
Keywords: lis1; cholangiocarcinoma; mir 380; proliferation ... See more keywords
Interplay of LIS1 and MeCP2: Interactions and Implications With the Neurodevelopmental Disorders Lissencephaly and Rett Syndrome
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2019.00370
Abstract: LIS1 is the main causative gene for lissencephaly, while MeCP2 is the main causative gene for Rett syndrome, both of which are neurodevelopmental diseases. Here we report nuclear functions for LIS1 and identify previously unrecognized… read more here.
Keywords: rett syndrome; mecp2; disorders lissencephaly; lis1 ... See more keywords