Rifampicin ameliorates lithium‐pilocarpine‐induced seizures, consequent hippocampal damage and memory deficit in rats: Impact on oxidative, inflammatory and apoptotic machineries
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.09.004
Abstract: Graphical abstract Figure. No Caption available. Abstract Epilepsy is one of the serious neurological sequelae of bacterial meningitis. Rifampicin, the well‐known broad spectrum antibiotic, is clinically used for chemoprophylaxis of meningitis. Besides its antibiotic effects,… read more here.
Keywords: meningitis; rifampicin; rifampicin pretreatment; inflammatory ... See more keywords
Predicting signaling pathways regulating demyelination in a rat model of lithium-pilocarpine-induced acute epilepsy: A proteomics study.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.10.209
Abstract: Demyelination is observed in animal models of intractable epilepsy (IE). Epileptogenesis damages the myelin sheath and dysregulates oligodendrocyte precursor cell (OPC) development. However, the molecular pathways regulating demyelination in epilepsy are unclear. Here, we predicted… read more here.
Keywords: epilepsy; demyelination; regulating demyelination; lithium pilocarpine ... See more keywords
Rosiglitazone Prevents Autophagy by Regulating Nrf2-Antioxidant Response Element in a Rat Model of Lithium-pilocarpine-induced Status Epilepticus
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2020.10.026
Abstract: Status epilepticus (SE) leads to irreversible neuronal damage and consists of a complex pathogenesis that involves oxidative stress and subsequent autophagy. Rosiglitazone has recently been considered as a potential neuroprotective factor in epilepsy because of… read more here.
Keywords: status epilepticus; pilocarpine induced; rosiglitazone; lithium pilocarpine ... See more keywords
Citral Effects on the Expression Profile of Brain-Derived Neurotrophic Factor and Inflammatory Cytokines in Status Epilepticus-Induced Rats Using the Lithium-Pilocarpine Model.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal food"
DOI: 10.1089/jmf.2020.0073
Abstract: Epilepsy is one of the most common neurological disorders. About one-third of people with epilepsy are refractory to available treatments. Studies suggest that mechanisms linked to the immune response and inflammatory process are related to… read more here.
Keywords: pilocarpine model; epilepticus induced; status epilepticus; inflammatory ... See more keywords
Glycyrrhizin, an HMGB1 inhibitor, exhibits neuroprotective effects in rats after lithium‐pilocarpine‐induced status epilepticus
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pharmacy and Pharmacology"
DOI: 10.1111/jphp.13040
Abstract: It has been proven that extracellular HMGB1 is involved in progression of neurologic disorders, such as stroke, traumatic brain injury, meningitis and epilepsy. Glycyrrhizin (GL) is a direct inhibitor of HMGB1, and blocks HMGB1 release… read more here.
Keywords: neuroprotective effects; pilocarpine induced; glycyrrhizin; status epilepticus ... See more keywords
Early morphological and functional changes in the GABAergic system of hippocampus in the rat lithium-pilocarpine model of epilepsy
Sign Up to like & getrecommendations! Published in 2017 at "Doklady Biological Sciences"
DOI: 10.1134/s0012496617010045
Abstract: We studied early alterations in the GABAergic system of the rat hippocampus in the lithium–pilocarpine model of epilepsy. Twenty-four hours after the pilocarpine treatment, a decrease in the number of calretinin-positive interneurons was observed in… read more here.
Keywords: gabaergic system; pilocarpine model; lithium pilocarpine; rat ... See more keywords
Thalidomide Attenuates Epileptogenesis and Seizures by Decreasing Brain Inflammation in Lithium Pilocarpine Rat Model
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076488
Abstract: Thalidomide (TAL) has shown potential therapeutic effects in neurological diseases like epilepsy. Both clinical and preclinical studies show that TAL may act as an antiepileptic drug and as a possible treatment against disease development. However,… read more here.
Keywords: brain; lithium pilocarpine; lithium; thalidomide attenuates ... See more keywords
Expression of Cytokines and Neurodegeneration in the Rat Hippocampus and Cortex in the Lithium-Pilocarpine Model of Status Epilepticus and the Role of Modulation of Endocannabinoid System
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076509
Abstract: A significant body of evidence shows that neuroinflammation is one of the key processes in the development of brain pathology in trauma, neurodegenerative disorders, and epilepsy. Various brain insults, including severe and prolonged seizure activity… read more here.
Keywords: modulation endocannabinoid; status epilepticus; lithium pilocarpine; expression ... See more keywords
Antagonist targeting microRNA-146a protects against lithium-pilocarpine-induced status epilepticus in rats by nuclear factor-κB pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular medicine reports"
DOI: 10.3892/mmr.2018.8465
Abstract: Previous studies have indicated that nuclear factor-κB (NF-κB) has an important role in the pathogenesis of epilepsy. The aim of the present study was to evaluate the expression of microRNA (miRNA)‑146a, phosphorylated (p)‑P65/P65, B‑cell lymphoma‑2(Bcl‑2)/Bcl‑2‑associated… read more here.
Keywords: mir 146a; expression; lithium pilocarpine; nuclear factor ... See more keywords