Facially amphiphilic polyionene biocidal polymers derived from lithocholic acid
Sign Up to like & getrecommendations! Published in 2018 at "Bioactive Materials"
DOI: 10.1016/j.bioactmat.2018.02.001
Abstract: Bacterial infections have become a global issue that requires urgent attention, particularly regarding to emergence of multidrug resistant bacteria. We developed quaternary amine-containing antimicrobial poly(bile acid)s that contain a hydrophobic core of lithocholic acid in… read more here.
Keywords: biocidal polymers; amphiphilic polyionene; polyionene biocidal; lithocholic acid ... See more keywords
Electrophoretic deposition of materials using lithocholic acid as a dispersant
Sign Up to like & getrecommendations! Published in 2020 at "Materials Letters"
DOI: 10.1016/j.matlet.2020.128129
Abstract: Abstract Lithocholic acid (LCA) was used as an anionic biosurfactant for the dispersion and electrophoretic deposition (EPD) of electrically neutral materials, such as poly(tetrafluoroethylene) (PTFE) and diamond from suspensions in ethanol. The steroid structure of… read more here.
Keywords: ptfe diamond; lca; deposition; lithocholic acid ... See more keywords
Vitamin E analogues differentially inhibit human cytochrome P450 3A (CYP3A)-mediated oxidative metabolism of lithocholic acid: Impact of δ-tocotrienol on lithocholic acid cytotoxicity.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology"
DOI: 10.1016/j.tox.2019.05.005
Abstract: Lithocholic acid is a cytotoxic bile acid oxidized at the C-3 position by human cytochrome P450 3A (CYP3A) to form 3-ketocholanoic acid, but it is not known whether this metabolite is cytotoxic. Tocotrienols, in their… read more here.
Keywords: tocotrienol; lithocholic acid; vitamin; acid ... See more keywords
The Effect of Lithocholic Acid on the Gut-Liver Axis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.910493
Abstract: Lithocholic acid (LCA) is a monohydroxy bile acid produced by intestinal flora, which has been found to be associated with a variety of hepatic and intestinal diseases. LCA is previously considered to be toxic, however,… read more here.
Keywords: lithocholic acid; acid; liver axis; gut liver ... See more keywords
Lithocholic Acid Amides as Potent Vitamin D Receptor Agonists
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12010130
Abstract: 1α,25-Dihydroxyvitamin D3 [1α,25(OH)2D3, 1] is an active form of vitamin D3 and regulates various biological phenomena, including calcium and phosphate homeostasis, bone metabolism, and immune response via binding to and activation of vitamin D receptor… read more here.
Keywords: lithocholic acid; vitamin receptor; amides potent; acid amides ... See more keywords
Possible Role of Bent Structure of Methylated Lithocholic Acid on Artificial and Plasma Membranes
Sign Up to like & getrecommendations! Published in 2022 at "Membranes"
DOI: 10.3390/membranes12100997
Abstract: Bile acids form micelles that are essential for the absorption of dietary lipids. However, excessive bile acid micelles can disrupt the plasma membrane by removing phospholipids, resulting in cell death. We hypothesized that the bent… read more here.
Keywords: structure; lca; bent structure; lithocholic acid ... See more keywords
Synthesis and Biological Evaluation of 3-Amino-4,4-Dimethyl Lithocholic Acid Derivatives as Novel, Selective, and Cellularly Active Allosteric SHP1 Activators
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28062488
Abstract: Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP1), a non-receptor member of the protein tyrosine phosphatase (PTP) family, negatively regulates several signaling pathways that are responsible for pathological cell processes in cancers. In this… read more here.
Keywords: shp1 activators; dimethyl lithocholic; amino dimethyl; lithocholic acid ... See more keywords