Analysis of incidence data in developmental toxicity studies: Statistical tests to account for litter effects in fetal defect data
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DOI: 10.1002/bdr2.2120
Abstract: When analyzing fetal defect incidence in laboratory animal studies, correlation in responses within litters (i.e., litter effects) can lead to increased false‐positive rates if litter effects are not incorporated into the analysis. Studies of fetal… read more here.
Keywords: analysis incidence; incidence; fetal defect; incidence data ... See more keywords
Controlling litter effects to enhance rigor and reproducibility with rodent models of neurodevelopmental disorders
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neurodevelopmental Disorders"
DOI: 10.1186/s11689-020-09353-y
Abstract: Research with rodents is crucial for expanding our understanding of genetic and environmental risk factors for neurodevelopmental disorders (NDD). However, there is growing concern about the number of animal studies that are difficult to replicate,… read more here.
Keywords: litter effects; controlling litter; litter; reproducibility ... See more keywords