A profile of the live biotherapeutic product RBX2660 and its role in preventing recurrent Clostridioides difficile infection
Sign Up to like & getrecommendations! Published in 2023 at "Expert Review of Anti-infective Therapy"
DOI: 10.1080/14787210.2023.2171986
Abstract: ABSTRACT Introduction Clostridiodes difficile infection (CDI) is a life-threatening illness that has been labelled as an urgent threat by the Centers for Disease prevention (CDC). Areas Covered RBX2660, a live biotherapeutic product offers a very… read more here.
Keywords: live biotherapeutic; infection; rbx2660; biotherapeutic product ... See more keywords
Abstract 6201: Live biotherapeutic MRx0518 as a modulator of immune responses in intestinal tissue and breast tumor microenvironment
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-6201
Abstract: Introduction: The human gut microbiota plays a role in modulating both intestinal and systemic immunity. Its importance in regulating anti-tumorigenic responses is now being explored, supported by evidence that the functional profile of the gut… read more here.
Keywords: microenvironment; tumor; live biotherapeutic; immune responses ... See more keywords
Treating Clostridioides difficile: Could Microbiota-based Live Biotherapeutic Products Provide the Answer?
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DOI: 10.2147/idr.s400570
Abstract: Abstract Clostridioides difficile infection (CDI) is a pressing health care issue due to the limited effectiveness of current treatments and high recurrence rates. Current available antibiotic options for CDI disrupt the fecal microbiome which predisposes… read more here.
Keywords: live biotherapeutic; clostridioides difficile; microbiota based; based live ... See more keywords
Microbiome engineering: engineered live biotherapeutic products for treating human disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.1000873
Abstract: The human microbiota is implicated in many disease states, including neurological disorders, cancer, and inflammatory diseases. This potentially huge impact on human health has prompted the development of microbiome engineering methods, which attempt to adapt… read more here.
Keywords: engineered live; live biotherapeutic; biotherapeutic products; microbiome ... See more keywords
Live Biotherapeutic Products, A Road Map for Safety Assessment
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DOI: 10.3389/fmed.2020.00237
Abstract: Recent developments in the understanding of the relationship between the microbiota and its host have provided evidence regarding the therapeutic potential of selected microorganisms to prevent or treat disease. According to Directive 2001/83/EC, in the… read more here.
Keywords: safety assessment; biotherapeutic products; live biotherapeutic; safety ... See more keywords
Entering First-in-Human Clinical Study With a Single-Strain Live Biotherapeutic Product: Input and Feedback Gained From the EMA and the FDA
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2021.716266
Abstract: During the last decade, a plethora of novel therapies containing live microorganisms as active substance(s) has emerged with the aim to treat, prevent, or cure diseases in human beings. Both the Food and Drug Administration… read more here.
Keywords: live biotherapeutic; human clinical; entering first; single strain ... See more keywords
Editorial: Synthetic Live Biotherapeutic Products for Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.882743
Abstract: Host-microbiota interactions have increasingly been shown to play important roles in supporting host health (Brown et al., 2019; Janney et al., 2020). In human, the gut microbiota contributes to several metabolic and immune-mediated diseases, such… read more here.
Keywords: live biotherapeutic; microbiota interactions; microbiota; synthetic live ... See more keywords