α‐Synuclein Sequences from Long‐Lived Animals Display Generally Diminished Aggregation Compared to Shorter‐Lived Animals Including Humans
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DOI: 10.1002/cbic.202500340
Abstract: The overall process of protein aggregation from soluble species to amyloid fibrils is toxic to neurons and can propagate along neuronal connections in ways that potentially explain the pathological progression in most neurodegenerative diseases. One… read more here.
Keywords: sequences long; animals display; shorter lived; synuclein sequences ... See more keywords
Long-lived animals with negligible senescence: clues for ageing research.
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DOI: 10.1042/bst20190105
Abstract: Among several theories to explain the complicated process of human ageing, the mitochondrial oxidative stress hypothesis has received recent attention. Considering that lifespan and ageing rates vary considerably across taxa, a better understanding of factors… read more here.
Keywords: senescence; long lived; lived animals; negligible senescence ... See more keywords
Multidimensional phenotyping predicts lifespan and quantifies health in Caenorhabditis elegans
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DOI: 10.1371/journal.pcbi.1008002
Abstract: Ageing affects a wide range of phenotypes at all scales, but an objective measure of ageing remains challenging, even in simple model organisms. To measure the ageing process, we characterized the sequence of alterations of… read more here.
Keywords: remaining life; age; multidimensional phenotyping; lived animals ... See more keywords