Determination of drugs in exhumed liver and brain tissue after over 9 years of burial by LC-MS/MS Part 1: Cardiovascular drugs.
Sign Up to like & getrecommendations! Published in 2020 at "Drug testing and analysis"
DOI: 10.1002/dta.2940
Abstract: This paper presents analytical results of cardiovascular drugs which were determined in exhumed liver and brain tissue in a total of 115 cases. Exhumations were executed after 9.5-16.5 years of burial. Analysis was performed by… read more here.
Keywords: brain tissue; exhumed liver; cardiovascular drugs; liver brain ... See more keywords
Effect of Metabolic Stress on Lysosomal Proteolysis in the Liver and Brain of Rats Receiving Q10-Enriched Ration
Sign Up to like & getrecommendations! Published in 2018 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-018-4156-0
Abstract: Activation of lysosomal proteolysis and increased coenzyme Q10 level were revealed in the liver and brain of rats with individual typological features under conditions of food deprivation. Changes in cathepsin B activity in these tissues… read more here.
Keywords: lysosomal proteolysis; metabolic stress; liver brain; brain rats ... See more keywords
Similar effect of sodium nitroprusside and acetylsalicylic acid on antioxidant system improvement in mouse liver but not in the brain.
Sign Up to like & getrecommendations! Published in 2017 at "Biochimie"
DOI: 10.1016/j.biochi.2017.02.006
Abstract: BACKGROUND The aim of the present study was to analyze the relative antioxidant effects of acetylsalicylic acid (ASA) and sodium nitroprusside (SNP) in mouse liver and brain. METHODS The activity of rhodanese, 3-mercaptopyruvate sulfurtransferase (MPST)… read more here.
Keywords: antioxidant; acetylsalicylic acid; liver brain; sodium nitroprusside ... See more keywords
Evaluation of muscle tissue as a non-lethal proxy for liver and brain organic contaminant loads in an elasmobranch, the Bonnethead Shark (Sphyrna tiburo).
Sign Up to like & getrecommendations! Published in 2021 at "Marine pollution bulletin"
DOI: 10.1016/j.marpolbul.2021.112327
Abstract: Elasmobranch ecotoxicological investigations are complicated because accessing organs that accumulate organic contaminants is usually lethal. Several metrics among liver, muscle, and brain were evaluated to determine their relative organic contaminant loads and the efficacy of… read more here.
Keywords: muscle; organic contaminant; non lethal; liver brain ... See more keywords
Organ and brain crosstalk: The liver-brain axis in gastrointestinal, liver, and pancreatic diseases
Sign Up to like & getrecommendations! Published in 2022 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2021.108915
Abstract: The liver is the largest organ in the human body and is responsible for the metabolism and storage of the three principal nutrients: carbohydrates, fats, and proteins. In addition, the liver contributes to the breakdown… read more here.
Keywords: liver brain; liver; brain axis; brain ... See more keywords
The liver-brain-gut neural arc maintains the Treg cell niche in the gut.
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/s41586-020-2425-3
Abstract: The gut-brain axis, a reciprocal interaction between the central nervous system (CNS) and peripheral intestinal functions, is conceptually feasible from recent clinical and experimental evidence showing mutual interactions between the CNS and gut microbiota that… read more here.
Keywords: gut; arc; brain gut; liver brain ... See more keywords
Liver and brain differential expression of one-carbon metabolism genes during ontogenesis.
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DOI: 10.1038/s41598-021-00311-9
Abstract: One-carbon metabolism (1C metabolism) is of paramount importance for cell metabolism and mammalian development. It is involved in the synthesis or modification of a wide variety of compounds such as proteins, lipids, purines, nucleic acids… read more here.
Keywords: metabolism; liver brain; expression; one carbon ... See more keywords
Tea combats circadian rhythm disorder syndrome via the gut-liver-brain axis: potential mechanisms speculated.
Sign Up to like & getrecommendations! Published in 2022 at "Critical reviews in food science and nutrition"
DOI: 10.1080/10408398.2022.2040945
Abstract: Circadian rhythm is an intrinsic mechanism developed by organisms to adapt to external environmental signals. Nowadays, owing to the job and after-work entertainment, staying up late - Circadian rhythm disorders (CRD) are common. CRD is… read more here.
Keywords: crd; liver brain; brain axis; gut liver ... See more keywords
Chronic valproic acid administration enhances oxidative stress, upregulates IL6 and downregulates Nrf2, Glut1 and Glut4 in rat’s liver and brain
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DOI: 10.1097/wnr.0000000000001663
Abstract: Supplemental Digital Content is available in the text. Valproic acid (VPA) is a powerful antiepileptic drug that was associated with several neurological and hepatic problems especially with increasing its dose and duration. These problems may… read more here.
Keywords: glut1 glut4; liver brain; oxidative stress;
Energy Drink Induced Lipid Peroxidation and Oxidative Damage in Rat Liver and Brain When Used Alone or Combined with Alcohol.
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DOI: 10.1111/1750-3841.13662
Abstract: Energy drinks (ED) are containing large doses of metabolic stimulants and its use with ethanol has increased dramatically among young adults. In this study, we examined the effects of ED exposure either alone or in… read more here.
Keywords: oxidative damage; liver brain; lipid peroxidation; liver ... See more keywords
Unveiling the tumor immune microenvironment of organ-specific melanoma metastatic sites
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-004884
Abstract: Background The liver is a known site of resistance to immunotherapy and the presence of liver metastases is associated with shorter progression-free and overall survival (OS) in melanoma, while lung metastases have been associated with… read more here.
Keywords: liver; melanoma; immune microenvironment; brain ... See more keywords