Nanosecond pulsed electric field ablation-induced modulation of sphingolipid metabolism is associated with Ly6c2+ mononuclear phagocyte differentiation in liver cancer.
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DOI: 10.1002/1878-0261.13372
Abstract: Preclinical studies have proven that nanosecond pulsed electric field (nsPEF) ablation can be a safe and effective treatment for humans with unresectable liver cancer that are ineligible for thermal ablation. The concomitant activation of antitumor… read more here.
Keywords: sphingolipid metabolism; nanosecond pulsed; liver cancer; ablation ... See more keywords
Identification of modules and novel prognostic biomarkers in liver cancer through integrated bioinformatics analysis
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DOI: 10.1002/2211-5463.12983
Abstract: Liver cancer is a common malignant tumor with poor prognosis. Due to the lack of specific clinical manifestations at early stages, most patients are already at advanced stages of the disease by the time of… read more here.
Keywords: biomarkers liver; analysis; mir; prognostic biomarkers ... See more keywords
Small Molecule‐Induced Differentiation As a Potential Therapy for Liver Cancer
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DOI: 10.1002/advs.202103619
Abstract: Despite the efficacy demonstrated by immunotherapy recently, liver cancer still remains one of the deadliest cancers, mainly due to heterogeneity of this disease. Continuous exploration of new therapeutics is therefore necessary. Chemical‐induced cell differentiation can… read more here.
Keywords: small molecule; liver cancer; cancer; induced differentiation ... See more keywords
Targeting mTORC2/HDAC3 Inhibits Stemness of Liver Cancer Cells Against Glutamine Starvation
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DOI: 10.1002/advs.202103887
Abstract: Cancer cells are addicted to glutamine. However, cancer cells often suffer from glutamine starvation, which largely results from the fast growth of cancer cells and the insufficient vascularization in the interior of cancer tissues. Herein,… read more here.
Keywords: cancer; liver cancer; glutamine starvation; hdac3 ... See more keywords
Elevated Nuclear PHGDH Synergistically Functions with cMyc to Reshape the Immune Microenvironment of Liver Cancer.
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DOI: 10.1002/advs.202205818
Abstract: Herein, we observed that nuclear localization of phosphoglycerate dehydrogenase (PHGDH) is associated with poor prognosis in liver cancer, and Phgdh is required for liver cancer progression in a mouse model. Unexpectedly, impairment of Phgdh enzyme… read more here.
Keywords: nuclear phgdh; phgdh; elevated nuclear; liver cancer ... See more keywords
Nano Ultrasound Contrast Agent for Synergistic Chemo-photothermal Therapy and Enhanced Immunotherapy Against Liver Cancer and Metastasis.
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DOI: 10.1002/advs.202300878
Abstract: Advanced liver cancer is the most fatal malignant cancer, and the clinical outcomes of treatment are not very satisfactory due to the complexity and heterogeneity of the tumor. Combination therapy can efficiently enhance tumor treatment… read more here.
Keywords: metastasis; liver cancer; therapy; delivery ... See more keywords
Tumor‐associated macrophages in liver cancer: From mechanisms to therapy
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DOI: 10.1002/cac2.12345
Abstract: Multidimensional analyses have demonstrated the presence of a unique tumor microenvironment (TME) in liver cancer. Tumor‐associated macrophages (TAMs) are among the most abundant immune cells infiltrating the TME and are present at all stages of… read more here.
Keywords: cancer; liver cancer; macrophages liver; cancer cells ... See more keywords
Investigation of Plasma cell‐free cancer genome chromosomal instability as a tool for targeted minimally invasive biomarkers for primary liver cancer diagnoses
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DOI: 10.1002/cam4.3142
Abstract: To characterize plasma cell‐free cancer genome chromosomal instabilities (CIN) in patients with liver cancer and to evaluate the potential of CIN as minimally invasive biomarkers for primary liver cancer (PLC) diagnoses. read more here.
Keywords: cancer genome; plasma cell; cell free; free cancer ... See more keywords
The burden of primary liver cancer caused by specific etiologies from 1990 to 2019 at the global, regional, and national levels
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DOI: 10.1002/cam4.4530
Abstract: Liver cancer is one of the most common cancers worldwide. We aimed to report the burden of liver cancer at the global, regional, and national levels in 204 countries from 1990 to 2019, stratified by… read more here.
Keywords: liver cancer; 1990 2019; global regional; regional national ... See more keywords
Long noncoding RNA HULC regulates the NF‐κB pathway and represents a promising prognostic biomarker in liver cancer
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DOI: 10.1002/cam4.5263
Abstract: Long noncoding RNAs (lncRNAs) are involved in a diverse array of biological processes. While lncRNAs are commonly upregulated in hepatocellular carcinoma (HCC), the specific regulatory roles they play in this oncogenic context require further study… read more here.
Keywords: liver cancer; long noncoding; rna hulc; cancer ... See more keywords
PIK3R3 is upregulated in liver cancer and activates Akt signaling to control cancer growth by regulation of CDKN1C and SMC1A.
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DOI: 10.1002/cam4.6068
Abstract: BACKGROUND Liver cancer is a highly malignant disease and the third leading cause of cancer death worldwide. Abnormal activation of PI3K/Akt signaling is common in cancer, but whether phosphoinositide-3-kinase regulatory subunit 3 (PIK3R3) plays a… read more here.
Keywords: liver cancer; pik3r3; growth; akt signaling ... See more keywords