Liraglutide enhances the effect of checkpoint blockade through the inhibition of neutrophil extracellular traps in murine lung and liver cancers.
Sign Up to like & getrecommendations! Published in 2022 at "FEBS open bio"
DOI: 10.1002/2211-5463.13499
Abstract: Glucagon-like peptide-1 (GLP-1) regulates glycemic excursions by augmenting insulin production and inhibiting glucagon secretion. Liraglutide, a long-acting GLP-1 analog, can improve glycemic control for treating type 2 diabetes and prevent neutrophil extravasation in inflammation. Here,… read more here.
Keywords: inhibition; lung liver; liver cancers; murine lung ... See more keywords
Evaluation of Primary Liver Cancers Using Hepatocyte‐Specific Contrast‐Enhanced MRI: Pitfalls and Potential Tips
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Magnetic Resonance Imaging"
DOI: 10.1002/jmri.27213
Abstract: When radiologists interpret hepatic focal lesions seen on dynamic magnetic resonance imaging (MRI) scans, it is important not only to distinguish malignant lesions from benign ones but also to distinguish nonhepatocellular carcinoma (HCC) malignancies from… read more here.
Keywords: hcc; contrast; evaluation primary; liver ... See more keywords
Fluorescence imaging in the surgical management of liver cancers: Current status and future perspectives.
Sign Up to like & getrecommendations! Published in 2021 at "Asian journal of surgery"
DOI: 10.1016/j.asjsur.2021.08.063
Abstract: Over the last decades, imaging technologies have got significant developments and become indispensable in the surgical management of liver cancers. Real-time navigation afforded by intraoperative images has a significant impact on the success of liver… read more here.
Keywords: fluorescence imaging; liver; surgical management; management liver ... See more keywords
Genomic Profiling and Metabolic Homeostasis in Primary Liver Cancers.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in molecular medicine"
DOI: 10.1016/j.molmed.2018.02.006
Abstract: Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA), the two most common primary liver cancers, represent the second most common cancer-related cause of death worldwide, with most cases being diagnosed at an advanced stage. Recent genome-wide… read more here.
Keywords: metabolic homeostasis; liver; primary liver; profiling metabolic ... See more keywords
Well-differentiated liver cancers reveal the potential link between ACE2 dysfunction and metabolic breakdown
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-021-03710-0
Abstract: Angiotensin-converting enzyme 2 (ACE2) is the receptor of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causing Coronavirus disease 2019 (COVID-19). Transmembrane serine protease 2 (TMPRSS2) is a coreceptor. Abnormal hepatic function in COVID-19 suggests… read more here.
Keywords: dysfunction metabolic; metabolic breakdown; ace2 tmprss2; liver cancers ... See more keywords
Technology of irreversible electroporation and review of its clinical data on liver cancers
Sign Up to like & getrecommendations! Published in 2018 at "Expert Review of Medical Devices"
DOI: 10.1080/17434440.2018.1425612
Abstract: ABSTRACT Introduction: Irreversible electroporation (IRE) has developed as a novel percutaneous ablative technique over the past decade and its utility in the treatment of primary and metastatic liver disease has progressed rapidly. Areas covered: After… read more here.
Keywords: irreversible electroporation; treatment; liver; technology ... See more keywords
Abstract CT096: Phase 1 study of RO7119929 (TLR7 agonist prodrug) in patients (pts) with advanced primary or metastatic liver cancers
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-ct096
Abstract: Background Agonists for TLR7, a major regulator of the innate immune response, have been tested in oncology across several nonclinical and clinical investigations due to their ability to stimulate T-cell mediated cancer cell killing. The… read more here.
Keywords: liver cancers; agonist prodrug; crs; study ... See more keywords
Role of zonula occludens in gastrointestinal and liver cancers
Sign Up to like & getrecommendations! Published in 2022 at "World Journal of Clinical Cases"
DOI: 10.12998/wjcc.v10.i12.3647
Abstract: A growing body of evidence suggests that tight junction (TJ) proteins play a crucial role in the pathogenesis of various diseases, including gastrointestinal (GI) cancer and hepatocellular carcinoma (HCC). TJ proteins primarily maintain the epithelial… read more here.
Keywords: zonula occludens; role; liver cancers; hcc ... See more keywords
The Orphan Nuclear Receptor Gene NR0B2 Is a Favorite Prognosis Factor Modulated by Multiple Cellular Signal Pathways in Human Liver Cancers
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.691199
Abstract: Background Liver cancer is a leading cause of cancer death worldwide, and novel prognostic factor is needed for early detection and therapeutic responsiveness monitoring. The orphan nuclear receptor NR0B2 was reported to suppress liver cancer… read more here.
Keywords: liver; expression; cancer; nr0b2 gene ... See more keywords
Oncostatin M: From Intracellular Signaling to Therapeutic Targets in Liver Cancer
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DOI: 10.3390/cancers14174211
Abstract: Simple Summary Pro-inflammatory cytokines play a key role in innate- and adaptive-immunity-mediated liver carcinogenesis. Among these, oncostatin M (OSM) critically contributes to physiological and pathological processes, including extracellular matrix remodeling, hematopoiesis, differentiation, inflammatory response, proliferation,… read more here.
Keywords: oncostatin intracellular; role; liver cancers; intracellular signaling ... See more keywords
Predicting Clinical Efficacy of Vascular Disrupting Agents in Rodent Models of Primary and Secondary Liver Cancers: An Overview with Imaging-Histopathology Correlation
Sign Up to like & getrecommendations! Published in 2020 at "Diagnostics"
DOI: 10.3390/diagnostics10020078
Abstract: Vascular disrupting agents (VDAs) have entered clinical trials for over 15 years. As the leading VDA, combretastatin A4 phosphate (CA4P) has been evaluated in combination with chemotherapy and molecular targeting agents among patients with ovarian… read more here.
Keywords: secondary liver; histopathology; liver; cancer ... See more keywords