A Beautiful Day in the Neighborhood: Application of Single‐Cell Transcriptomics to Unravel Liver Cell Heterogeneity in Diseased Human Livers
Sign Up to like & getrecommendations! Published in 2021 at "Hepatology"
DOI: 10.1002/hep.31827
Abstract: Kim and colleagues have taken advantage of recently developed computational methodology and advances in next generation sequencing of RNA isolates from individual cells and whole livers to characterize and compare differences in liver cell communities… read more here.
Keywords: single cell; neighborhood application; liver cell; application single ... See more keywords
Anti‐Inflammatory and Antioxidant Actions of Copaiba Oil Are Related to Liver Cell Modifications in Arthritic Rats
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25998
Abstract: The present study investigated the action of copaiba oil (Copaifera reticulata) on the systemic inflammation, oxidative status, and liver cell metabolism of rats with adjuvant‐induced arthritis. The later is an experimental autoimmune pathology that shares… read more here.
Keywords: anti inflammatory; liver cell; arthritic rats; inflammatory antioxidant ... See more keywords
microRNA‐30a inhibits the liver cell proliferation and promotes cell apoptosis through the JAK/STAT signaling pathway by targeting SOCS‐1 in rats with sepsis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28410
Abstract: Sepsis is a systemic inflammatory response that may be induced by trauma, infection, surgery, and burns. With the aim of discovering novel treatment targets for sepsis, this current study was conducted to investigate the effect… read more here.
Keywords: cell proliferation; mir 30a; socs; liver cell ... See more keywords
Therapeutic liver cell transplantation to treat murine PKU
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12802
Abstract: For gene therapy of the liver, in vivo applications based on adeno‐associated virus are the most advanced vectors despite limitations, including low efficacy and episomal loss, potential integration and safety issues, and high production costs.… read more here.
Keywords: cell transplantation; pku; liver cell; cell ... See more keywords
Intravital Imaging of Liver Cell Dynamics.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7762-8_13
Abstract: The liver is a vital organ in the body. It has various essential functions, including detoxification, protein synthesis, and control of infection. Because of its medical importance, liver diseases such as hepatitis and cirrhosis can… read more here.
Keywords: cell dynamics; intravital imaging; liver cell; liver ... See more keywords
PARP inhibitors and radiation potentiate liver cell death in vitro. Do hepatocellular carcinomas have an achilles' heel?
Sign Up to like & getrecommendations! Published in 2020 at "Clinics and research in hepatology and gastroenterology"
DOI: 10.1016/j.clinre.2020.09.014
Abstract: BACKGROUND A promising avenue for cancer treatment is exacerbating the deregulation of the DNA repair machinery that would normally protect the genome. To address the applicability of poly(ADP-ribose) polymerase (PARP) inhibitors (PARPi) combined with radiotherapy… read more here.
Keywords: dna damage; parp inhibitors; liver cell; control ... See more keywords
Cryopreservation of Liver-Cell Spheroids with Macromolecular Cryoprotectants
Sign Up to like & getrecommendations! Published in 2023 at "ACS Applied Materials & Interfaces"
DOI: 10.1021/acsami.2c18288
Abstract: Spheroids are a powerful tool for basic research and to reduce or replace in vivo (animal) studies but are not routinely banked nor shared. Here, we report the successful cryopreservation of hepatocyte spheroids using macromolecular… read more here.
Keywords: cell; cryopreservation liver; spheroids macromolecular; liver cell ... See more keywords
Genotoxic and mutagenic properties of atmospheric pressure plasma jet on human liver cell line L02
Sign Up to like & getrecommendations! Published in 2019 at "Physics of Plasmas"
DOI: 10.1063/1.5087148
Abstract: In clinical plasma medicine, the long-term safety is an important issue which needs to be addressed. In this study, normal human liver cell line L02 was chosen as an in vitro model to investigate the… read more here.
Keywords: cell line; plasma; liver cell; line l02 ... See more keywords
The Curative Effects of Vitamins D3&K2 on the Expressions of p53, Bax, Bcl-2, and Oxidative Stress Induced by Methotrexate in ZFL Epithelial Cells
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Medicinal Food"
DOI: 10.1089/jmf.2024.0261
Abstract: Methotrexate (MTX), a folate antimetabolite, is a cytotoxic drug known to cause cytotoxicity associated with free oxygen radicals. This study investigated the effect of vitamins D3 and K2 on MTX-induced liver cell injury using the… read more here.
Keywords: methotrexate; liver cell; expressions p53; bax bcl ... See more keywords
Di (2-Ethylhexyl) Phthalate and Its Role in Developing Cholestasis: An In Vitro Study on Different Liver Cell Types
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pediatric Gastroenterology and Nutrition"
DOI: 10.1097/mpg.0000000000001813
Abstract: Objectives: Di(2-ethylhexyl) phthalate (DEHP) is a plasticizer used in many polyvinylchloride medical devices and is washed out easily. Thereby critically ill infants can become exposed to DEHP concentrations significantly exceeding the recommended threshold. We suspect… read more here.
Keywords: dehp; liver cell; different liver; cell types ... See more keywords
Advances on liver cell‐derived exosomes in liver diseases
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16123
Abstract: Exosomes are extracellular vesicles with diameters ranging from 30 to 150 nm, which contain several donor cell‐associated proteins as well as mRNA, miRNA, and lipids and coordinate multiple physiological and pathological functions through horizontal communication… read more here.
Keywords: liver cell; cell derived; liver diseases; liver ... See more keywords