Gut–liver on a chip toward an in vitro model of hepatic steatosis
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26793
Abstract: Hepatic steatosis is a process of abnormal lipid deposition within the liver cells, often caused by excessive alcohol uptake or obesity. A conventional in vitro model for hepatic steatosis uses a liver cell culture, treated… read more here.
Keywords: liver chip; hepatic steatosis; model; gut liver ... See more keywords
Liver‐on‐a‐Chip Models of Fatty Liver Disease
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology"
DOI: 10.1002/hep.31106
Abstract: As a consequence of the obesity epidemic and increasing incidence of metabolic syndrome fatty liver disease now affects a large portion of the world's population. Left untreated, fatty liver disease can progress to more severe… read more here.
Keywords: liver disease; liver chip; fatty liver; disease ... See more keywords
3D-Printed Impedance Micropump for Continuous Perfusion of the Sample and Nutrient Medium Integrated with a Liver-On-Chip Prototype
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c03818
Abstract: In recent decades, organ-on-chip devices have gained substantial interest as an alternative for studying the pathophysiological processes relevant to drug screening. Micropumps are being utilized to simulate the in vivo physiological fluid flow more realistically… read more here.
Keywords: liver chip; impedance micropump; perfusion; micropump ... See more keywords
Miniature liver on a chip could boost US food safety
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature.2017.21818
Abstract: The goal is to compare these engineered organs to animal models, with an eye towards replacing animal testing. read more here.
Keywords: boost food; food safety; liver chip; miniature liver ... See more keywords
Liver-on-a-chip: Considerations, advances, and beyond.
Sign Up to like & getrecommendations! Published in 2022 at "Biomicrofluidics"
DOI: 10.1063/5.0106855
Abstract: The liver is the largest internal organ in the human body with largest mass of glandular tissue. Modeling the liver has been challenging due to its variety of major functions, including processing nutrients and vitamins,… read more here.
Keywords: liver; chip considerations; liver chip; considerations advances ... See more keywords
Applied Hepatic Bioengineering: Modeling the Human Liver Using Organoid and Liver-on-a-Chip Technologies
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.845360
Abstract: The liver is the most important metabolic hub of endo and xenobiotic compounds. Pre-clinical studies using rodents to evaluate the toxicity of new drugs and cosmetics may produce inconclusive results for predicting clinical outcomes in… read more here.
Keywords: chip technologies; liver; organoid liver; human liver ... See more keywords
Design and Fabrication of a Liver-on-a-chip Reconstructing Tissue-tissue Interfaces
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.959299
Abstract: Despite the rapid advances in the liver-on-a-chip platforms, it remains a daunting challenge to construct a biomimetic liver-on-a-chip for in vitro research. This study aimed to reconstruct the tissue-tissue interfaces based on bilayer microspheres and… read more here.
Keywords: bilayer microspheres; tissue interfaces; tissue tissue; liver chip ... See more keywords
Combined Femtosecond Laser Glass Microprocessing for Liver-on-Chip Device Fabrication
Sign Up to like & getrecommendations! Published in 2023 at "Materials"
DOI: 10.3390/ma16062174
Abstract: Nowadays, lab-on-chip (LOC) devices are attracting more and more attention since they show vast prospects for various biomedical applications. Usually, an LOC is a small device that serves a single laboratory function. LOCs show massive… read more here.
Keywords: femtosecond laser; fabrication; liver chip; device ... See more keywords
The Influence of Chronic Liver Diseases on Hepatic Vasculature: A Liver-on-a-chip Review
Sign Up to like & getrecommendations! Published in 2020 at "Micromachines"
DOI: 10.3390/mi11050487
Abstract: In chronic liver diseases and hepatocellular carcinoma, the cells and extracellular matrix of the liver undergo significant alteration in response to chronic injury. Recent literature has highlighted the critical, but less studied, role of the… read more here.
Keywords: liver chip; liver diseases; hepatic vasculature; liver ... See more keywords
Microfluidic Liver-on-a-Chip for Preclinical Drug Discovery
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15041300
Abstract: Drug discovery is an expensive, long, and complex process, usually with a high degree of uncertainty. In order to improve the efficiency of drug development, effective methods are demanded to screen lead molecules and eliminate… read more here.
Keywords: liver chip; drug discovery; loc; drug ... See more keywords