Liver Directed Adeno-Associated Viral Vectors to Treat Metabolic Disease.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of inherited metabolic disease"
DOI: 10.1002/jimd.12637
Abstract: The liver is the metabolic center of the body and an ideal target for gene therapy of inherited metabolic disorders (IMDs). Adeno-associated viral (AAV) vectors can deliver transgenes to the liver with high efficiency and… read more here.
Keywords: adeno associated; gene therapy; metabolic disease; liver directed ... See more keywords
Radiotherapy for Hepatocellular Carcinoma in Russia: a Survey-Based Analysis of Current Practice and the Impact of an Educational Workshop on Clinical Expertise
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cancer Education"
DOI: 10.1007/s13187-018-1447-0
Abstract: Radiation therapy (RT) is an effective treatment modality for hepatocellular carcinoma (HCC), but globally, it is underutilized. In Russia, practice patterns with regard to liver-directed radiation are unknown. Under the auspices of Russian Society of… read more here.
Keywords: workshop; hepatocellular carcinoma; hcc; russia ... See more keywords
Rescue of glutaric aciduria type I in mice by liver-directed therapies
Sign Up to like & getrecommendations! Published in 2023 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.adf4086
Abstract: Glutaric aciduria type I (GA-1) is an inborn error of metabolism with a severe neurological phenotype caused by the deficiency of glutaryl–coenzyme A dehydrogenase (GCDH), the last enzyme of lysine catabolism. Current literature suggests that… read more here.
Keywords: brain; aciduria type; glutaric aciduria; liver directed ... See more keywords
Defenestrated endothelium delays liver-directed gene transfer in hemophilia A mice.
Sign Up to like & getrecommendations! Published in 2022 at "Blood advances"
DOI: 10.1182/bloodadvances.2021006388
Abstract: Hemophilia A is an inherited bleeding disorder caused by defective or deficient coagulation factor-VIII (FVIII) activity. Until recently, the only treatment for prevention of bleeding involved intravenous administration of FVIII. Gene therapy with adeno associated… read more here.
Keywords: mice; directed gene; gene; liver directed ... See more keywords
Improving Adjuvant Liver-Directed Treatment Recommendations for Unresectable Hepatocellular Carcinoma: An Artificial Intelligence–Based Decision-Making Tool
Sign Up to like & getrecommendations! Published in 2022 at "JCO Clinical Cancer Informatics"
DOI: 10.1200/cci.22.00024
Abstract: PURPOSE Liver-directed therapy after transarterial chemoembolization (TACE) can lead to improvement in survival for selected patients with unresectable hepatocellular carcinoma (HCC). However, there is uncertainty in the appropriate application and modality of therapy in current… read more here.
Keywords: tace; liver directed; model; decision ... See more keywords
Liver-directed treatment for patients with uveal melanoma hepatic metastasis: A retrospective analysis of overall survival.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.9592
Abstract: 9592Background: Despite successful treatment of primary uveal melanomas, up to 50% of patients subsequently develop systemic metastasis, with the liver involved in up to 90% of patients. At our ins... read more here.
Keywords: treatment; treatment patients; metastasis; patients uveal ... See more keywords
Liver-directed therapy for hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Chinese clinical oncology"
DOI: 10.21037/cco-20-51
Abstract: The high mortality rate for hepatocellular carcinoma (HCC) relative to its prevalence underscores the need for curative-intent therapies. Multidisciplinary treatment decisions are required to craft optimal treatment strategies considering tumor size, location and underlying liver… read more here.
Keywords: hepatocellular carcinoma; directed therapy; treatment; therapy ... See more keywords
Liver-Directed Treatment Options Following Liver Tumor Recurrence: A Review of the Literature
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.832405
Abstract: Recurrence following curative-intent hepatectomy for colorectal cancer liver metastasis, hepatocellular carcinoma, or cholangiocarcinoma is unfortunately common with a reported incidence as high as 75%. Various treatment modalities can improve survival following disease recurrence. A review… read more here.
Keywords: recurrence review; therapy; liver directed; treatment ... See more keywords
Liver-directed therapies for liver metastases from neuroendocrine neoplasms: Can laser ablation play any role?
Sign Up to like & getrecommendations! Published in 2020 at "World Journal of Gastroenterology"
DOI: 10.3748/wjg.v26.i23.3118
Abstract: Aggressive cytoreduction can prolong survival in patients with unresectable liver metastases (LM) from neuroendocrine neoplasms (NEN), and minimally invasive, liver-directed therapies are gaining increasing interest. Catheter-based treatments are used in disseminated disease, whereas ablation techniques… read more here.
Keywords: laser; ablation; metastases neuroendocrine; role ... See more keywords
Integration of Systemic and Liver-Directed Therapies for Locally Advanced Hepatocellular Cancer: Harnessing Potential Synergy for New Therapeutic Horizons.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the National Comprehensive Cancer Network : JNCCN"
DOI: 10.6004/jnccn.2021.7037
Abstract: Treatment options in locally advanced hepatocellular carcinoma (HCC) have evolved considerably over the past few years with the recent approval of multiple systemic therapies and significant advances in locoregional therapy. Given the poor prognosis for… read more here.
Keywords: systemic liver; advanced hepatocellular; integration systemic; cancer ... See more keywords