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   Articles with "liver disease" as a keyword



Association of Weight Loss Interventions With Changes in Biomarkers of Nonalcoholic Fatty Liver Disease

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recommendations! Published in 2019 at "JAMA Internal Medicine"

DOI: 10.1001/jamainternmed.2019.2248

Abstract: Key Points Question Are weight loss interventions associated with changes in biomarkers of liver disease in people with nonalcoholic fatty liver disease? Findings In this systematic review and meta-analysis of 22 randomized clinical trials with… read more here.

Keywords: nonalcoholic fatty; liver disease; weight loss; fatty liver ... See more keywords

Analysis of Severe Hypoglycemia Among Adults With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease

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recommendations! Published in 2022 at "JAMA Network Open"

DOI: 10.1001/jamanetworkopen.2022.0262

Abstract: Key Points Question Is nonalcoholic fatty liver disease (NAFLD) associated with severe hypoglycemia in individuals with type 2 diabetes? Findings In cohort study of more than 1.9 million individuals, participants with type 2 diabetes and… read more here.

Keywords: type diabetes; liver disease; fatty liver; severe hypoglycemia ... See more keywords

Hepatocellular Carcinoma in Metabolic Dysfunction-Associated Steatotic Liver Disease

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recommendations! Published in 2024 at "JAMA Network Open"

DOI: 10.1001/jamanetworkopen.2024.21019

Abstract: Key Points Question In patients with metabolic dysfunction–associated steatotic liver disease (MASLD), can those at high risk of developing hepatocellular carcinoma (HCC) be identified? Findings This prognostic study used electronic health record data from 1 811 461… read more here.

Keywords: steatotic liver; dysfunction associated; hepatocellular carcinoma; liver disease ... See more keywords
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Evaluation of Early vs Standard Liver Transplant for Alcohol-Associated Liver Disease.

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recommendations! Published in 2021 at "JAMA surgery"

DOI: 10.1001/jamasurg.2021.3748

Abstract: Importance Traditionally, liver transplant (LT) for alcohol-associated liver disease (ALD) requires 6 months of abstinence. Although early LT before 6 months of abstinence has been associated with decreased mortality for decompensated ALD, this practice remains… read more here.

Keywords: early standard; free survival; relapse free; liver disease ... See more keywords
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Transcription factor SOX2 contributes to nonalcoholic fatty liver disease development by regulating the expression of the fatty acid transporter CD36

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recommendations! Published in 2021 at "FEBS Letters"

DOI: 10.1002/1873-3468.14193

Abstract: Nonalcoholic fatty liver disease (NAFLD) can lead to hepatocellular carcinoma (HCC). The level of the transcription factor SOX2 correlates with HCC progression, but its role in fat accumulation remains unclear. Here, a high‐fat diet, with… read more here.

Keywords: fatty liver; cd36; transcription factor; sox2 ... See more keywords

Loss of EGFR contributes to high-fat diet-induced nonalcoholic fatty liver disease.

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recommendations! Published in 2023 at "FEBS letters"

DOI: 10.1002/1873-3468.14636

Abstract: Using a murine model of high-fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD), we found that the expression of the epidermal growth factor receptor (EGFR) significantly decreased in hepatocytes. In vitro, free fatty acid influx… read more here.

Keywords: fatty liver; high fat; egfr; liver disease ... See more keywords

Hepatic‐Accumulated Obeticholic Acid and Atorvastatin Self‐Assembled Nanocrystals Potentiate Ameliorative Effects in Treatment of Metabolic‐Associated Fatty Liver Disease

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202308866

Abstract: Exploration of medicines for efficient and safe management of metabolic‐associated fatty liver disease (MAFLD) remains a challenge. Obeticholic acid (OCA), a selective farnesoid X receptor agonist, has been reported to ameliorate injury and inflammation in… read more here.

Keywords: acid; associated fatty; metabolic associated; obeticholic acid ... See more keywords

Postbiotics From Lactobacillus Johnsonii Activates Gut Innate Immunity to Mitigate Alcohol‐Associated Liver Disease

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202405781

Abstract: Prolonged alcohol consumption disrupts the gut microbiota and the immune system, contributing to the pathogenesis of alcohol‐associated liver disease (ALD). Probiotic‐postbiotic intervention strategies can effectively relieve ALD by maintaining gut homeostasis. Herein, the efficacy of… read more here.

Keywords: lactobacillus johnsonii; associated liver; alcohol associated; johnsonii ... See more keywords

Free Cholesterol‐Induced Liver Injury in Non‐Alcoholic Fatty Liver Disease: Mechanisms and a Therapeutic Intervention Using Dihydrotanshinone I

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202406191

Abstract: Build‐up of free cholesterol (FC) substantially contributes to the development and severity of non‐alcoholic fatty liver disease (NAFLD). Here, we investigate the specific mechanism by which FC induces liver injury in NAFLD and propose a… read more here.

Keywords: free cholesterol; non alcoholic; alcoholic fatty; liver disease ... See more keywords

Chemogenomic Screening in a Patient‐Derived 3D Fatty Liver Disease Model Reveals the CHRM1‐TRPM8 Axis as a Novel Module for Targeted Intervention

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202407572

Abstract: Metabolic dysfunction‐associated steatohepatitis (MASH) is a leading cause of chronic liver disease with few therapeutic options. To narrow the translational gap in the development of pharmacological MASH treatments, a 3D liver model from primary human… read more here.

Keywords: patient derived; model; mash; chemogenomic screening ... See more keywords

Association Between Perfluoroalkyl Substance (PFAS) Exposure and Nonalcoholic Fatty Liver Disease in Korean Adults: Results From the KoNEHS 2018-2020: A Cross-Sectional Study.

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recommendations! Published in 2025 at "American journal of industrial medicine"

DOI: 10.1002/ajim.23732

Abstract: OBJECTIVES Nonalcoholic fatty liver disease (NAFLD) is a major public health problem and the most common chronic liver disease today. In Korea, the prevalence and incidence of NAFLD are currently very high, causing a serious… read more here.

Keywords: pfas; nonalcoholic fatty; perfluoroalkyl; association ... See more keywords