Updated Population Pharmacokinetic Model of Cabozantinib Integrating Various Cancer Types Including Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Pharmacology"
DOI: 10.1002/jcph.1467
Abstract: An integrated population pharmacokinetic (PPK) model was used to evaluate the effects of liver dysfunction on the pharmacokinetics (PK) of cabozantinib in patients with hepatocellular carcinoma and to determine whether clinical dosage adjustment may be… read more here.
Keywords: hepatocellular carcinoma; dysfunction; liver dysfunction; cancer ... See more keywords
Protective effect of autologous transplantation of resveratrol preconditioned adipose‐derived stem cells in the treatment of diabetic liver dysfunction in rat model
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.2917
Abstract: Previous studies stated that stem cell functions are reduced under high glucose environment, leading to reduce stem cell capability of tissue regeneration. This study aimed to investigate if stem cells preconditioned with resveratrol show better… read more here.
Keywords: resveratrol; stem cells; liver dysfunction; transplantation ... See more keywords
Risks and benefits of phase I liver dysfunction studies: should patients with severe liver dysfunction be included in these trials?
Sign Up to like & getrecommendations! Published in 2017 at "Investigational New Drugs"
DOI: 10.1007/s10637-017-0425-4
Abstract: SummaryIntroduction The goal of organ dysfunction Phase I trials is to characterize the safety and pharmacokinetics of novel agents in cancer patients with liver or kidney dysfunction, but the clinical benefit is not well established.… read more here.
Keywords: patients severe; dysfunction; liver dysfunction; severe liver ... See more keywords
Mitochondrial respiratory chain damage and mitochondrial fusion disorder are involved in liver dysfunction of fluoride-induced mice.
Sign Up to like & getrecommendations! Published in 2019 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2019.125099
Abstract: Our previous study showed that excessive fluoride (F) intake can induce liver dysfunction. The aim of this study was to investigate the mechanisms of F-induced mitochondrial damage resulting in liver dysfunction. Damaged mitochondrial ultrastructure and… read more here.
Keywords: mitochondrial respiratory; respiratory chain; dysfunction; liver dysfunction ... See more keywords
A systematic review and meta-analysis of immune-mediated liver dysfunction in non-small cell lung cancer.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106537
Abstract: BACKGROUND Immune checkpoint inhibitors (ICIs) have been identified as validated medications in non-small cell lung cancer (NSCLC). However, they are often associated with immune-related adverse events (irAEs) including liver dysfunction. Therefore, we conducted a systematic… read more here.
Keywords: immune; risk; dysfunction; liver dysfunction ... See more keywords
Liver Dysfunction in COVID-19: From Onset to Recovery.
Sign Up to like & getrecommendations! Published in 2022 at "Seminars in liver disease"
DOI: 10.1055/s-0042-1745871
Abstract: With the spread of coronavirus disease 2019 (COVID-19) worldwide, extrapulmonary lesions, including liver dysfunction, have attracted growing attention. The mechanisms underlying liver dysfunction in COVID-19 remain unclear. The reported prevalence of liver dysfunction varies widely… read more here.
Keywords: liver dysfunction; dysfunction; dysfunction covid; recovery ... See more keywords
Protective effect of aminoguanidine against lipopolysaccharide-induced hepatotoxicity and liver dysfunction in rat
Sign Up to like & getrecommendations! Published in 2019 at "Drug and Chemical Toxicology"
DOI: 10.1080/01480545.2018.1561712
Abstract: Abstract Lipopolysaccharide (LPS) as the major component of the outer membrane of Gram-negative bacteria activates macrophages to produce a high level of pro-inflammatory cytokines which is considered as a cause of liver dysfunction. Overproduction of… read more here.
Keywords: induced hepatotoxicity; lps induced; dysfunction; liver dysfunction ... See more keywords
Management of Liver Dysfunction Developing as an Immune-Related Adverse Event
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdz343.083
Abstract: Abstract Background The side effects of the immune checkpoint inhibitors are designated as immune-related adverse events (irAEs). Liver dysfunction is one of the well-known irAEs. According to the irAE guideline (JSMO), steroid treatment is definitely… read more here.
Keywords: immune related; treatment; dysfunction; liver dysfunction ... See more keywords
Association of liver dysfunction with outcomes after cardiac surgery—a meta-analysis
Sign Up to like & getrecommendations! Published in 2022 at "Interactive Cardiovascular and Thoracic Surgery"
DOI: 10.1093/icvts/ivac280
Abstract: Abstract OBJECTIVES The aim of this study was to perform a meta-analysis of studies reporting outcomes in patients with liver dysfunction addressed by the model of end-stage liver disease and Child–Turcotte–Pugh scores undergoing cardiac surgery.… read more here.
Keywords: liver dysfunction; mortality; dysfunction; cardiac surgery ... See more keywords
Outcome of patients with HCC and liver dysfunction under immunotherapy: a systematic review and meta-analysis
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DOI: 10.1097/hep.0000000000000030
Abstract: Background and Aims: Immunotherapy-based regimes have changed the management of HCC. However, evidence of efficacy in patients with impaired liver function is unknown. This systematic review and meta-analysis assesses survival of HCC patients and liver… read more here.
Keywords: review meta; liver dysfunction; meta analysis; immunotherapy ... See more keywords
How to continue lipid-lowering therapy in patients with coronary heart disease and severe liver dysfunction?
Sign Up to like & getrecommendations! Published in 2019 at "Medicine"
DOI: 10.1097/md.0000000000017664
Abstract: Abstract Rationale: Atherosclerotic cardiovascular disease (ASCVD), including coronary heart disease (CHD), atherosclerotic stroke and peripheral vascular disease, has become the most deadly chronic noncommunicable disease throughout the world in recent decades, while plaque regression could… read more here.
Keywords: liver dysfunction; medicine; severe liver; liver ... See more keywords