Structure-Activity Relationships of Flupirtine Analogues for the Liver Esterase-mediated Cleavage of the 4-Fluorobenzylamine Moiety and its possible Relevance to Liver Toxicity.
Sign Up to like & getrecommendations! Published in 2023 at "ChemMedChem"
DOI: 10.1002/cmdc.202300145
Abstract: Flupirtine and retigabine were essential drugs to combat pain and epilepsy. However, the Kv7 potassium channel openers are fraught with hepatotoxicity and tissue discoloration, respectively, limiting their therapeutic value. Both adverse events are likely due… read more here.
Keywords: structure activity; relationships flupirtine; liver esterase; flupirtine analogues ... See more keywords