MicroRNA‐Modified DNA Hexahedron‐Induced Hepatocyte‐Like Cells Integrating 3D Printed Scaffold for Acute Liver Failure Therapy
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DOI: 10.1002/adfm.202402339
Abstract: Acute liver failure (ALF) involves extensive necrosis of liver cells and severe impairment of liver function. Hepatocyte transplantation holds promise for treating ALF by swiftly supporting liver functions and promoting liver regeneration. However, the scarcity… read more here.
Keywords: like cells; hepatocyte; hepatocyte like; acute liver ... See more keywords
Bioinspired Artificial Liver System with hiPSC-derived Hepatocytes for Acute Liver Failure Treatment.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202101580
Abstract: Bioartificial liver (BAL) system has become a promising alternative to traditional liver transplantation in rescuing acute liver failure (ALF) patients. Herein, inspired by natural microstructure of hepatic lobules, we developed a novel biomimetic bioartificial liver… read more here.
Keywords: derived hepatocytes; liver failure; system; acute liver ... See more keywords
A Biomimetic Nanoparticle Exerting Protection Against Acute Liver Failure by Suppressing CYP2E1 Activity and Scavenging Excessive ROS.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300571
Abstract: Acute liver failure (ALF) is a severe liver disease caused by many reasons. One of them is the overdosed acetaminophen (APAP), which is metabolized into N-acetyl-p-benzoquinone imine (NAPQI), an excessive toxic metabolite, by CYP2E1, resulting… read more here.
Keywords: cyp2e1; liver; liver failure; acute liver ... See more keywords
Mas Signaling Potentiates Neutrophil Extracellular Traps Formation Induced by Endothelial Cells Derived S1P in Mice with Acute Liver Failure
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202411428
Abstract: Mas, a newly identified G‐protein‐coupled receptor, is prevalent in myeloid‐derived immune cells and plays a key role in inflammation. This study investigates Mas signaling and neutrophil extracellular traps (NETs) in acute liver failure (ALF), aiming… read more here.
Keywords: neutrophil extracellular; mas signaling; acute liver; liver failure ... See more keywords
Elevated FABP1 serum levels are associated with poorer survival in acetaminophen‐induced acute liver failure
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology"
DOI: 10.1002/hep.28945
Abstract: Acetaminophen (APAP)‐induced acute liver failure (ALF) is associated with significant mortality. Traditional prognostic scores lack sensitivity. Serum liver‐type fatty acid binding protein (FABP1) early (day 1) or late (day 3‐5) levels are associated with 21‐day… read more here.
Keywords: liver failure; acute liver; serum; liver ... See more keywords
Liver Transplant Listing in Pediatric Acute Liver Failure: Practices and Participant Characteristics
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DOI: 10.1002/hep.30116
Abstract: Liver transplant (LT) decisions in pediatric acute liver failure (PALF) are complex. Three phases of the PALF registry, containing data on 1,144 participants over 15 years, were interrogated to characterize clinical features associated with listing… read more here.
Keywords: liver failure; acute liver; liver; liver transplant ... See more keywords
Randomized Trial of Spheroid Reservoir Bioartificial Liver in Porcine Model of Posthepatectomy Liver Failure
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30184
Abstract: Acute liver failure (ALF) is a catastrophic condition that can occur after major liver resection. The aim of this study was to determine the effects of the spheroid reservoir bio‐artificial liver (SRBAL) on survival, serum… read more here.
Keywords: spheroid reservoir; liver failure; hours following; following hepatectomy ... See more keywords
Letter to the Editor: Surgical Method for Establishing Posthepatectomy Liver Failure
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology"
DOI: 10.1002/hep.31482
Abstract: We read with great interest the article by Chen et al. entitled "Randomized Trial of Spheroid Reservoir Bioartificial Liver in Porcine Model of Posthepatectomy Liver Failure". read more here.
Keywords: liver failure; letter editor; posthepatectomy liver; surgical method ... See more keywords
Acute on Chronic Liver Failure From Nonalcoholic Fatty Liver Disease: A Growing and Aging Cohort With Rising Mortality
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology"
DOI: 10.1002/hep.31566
Abstract: We assessed the burden of nonalcoholic fatty liver disease (NAFLD)‐related acute on chronic liver failure (ACLF) among transplant candidates in the United States, along with waitlist outcomes for this population. read more here.
Keywords: liver failure; fatty liver; nonalcoholic fatty; liver disease ... See more keywords
A Spotlight on the Drivers of Inflammation in Acute Liver Failure
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DOI: 10.1002/hep.31815
Abstract: Acute liver failure (ALF) is an important cause of mortality in the western world, accounting for 1600 deaths per year in the United States1 . However, surprisingly little is known about the cellular underpinnings of… read more here.
Keywords: spotlight drivers; drivers inflammation; liver failure; acute liver ... See more keywords
Follistatin-controlled activin-HNF4α-coagulation factor axis in liver progenitor cells determines outcome of acute liver failure.
Sign Up to like & getrecommendations! Published in 2021 at "Hepatology"
DOI: 10.1002/hep.32119
Abstract: BACKGROUND & AIMS In patients with acute liver failure (ALF) who suffer from massive hepatocyte loss, liver progenitor cells (LPC) take over key hepatocyte functions, which ultimately determines survival. This study investigated how the expression… read more here.
Keywords: coagulation; liver failure; follistatin; hnf4 ... See more keywords