PNPLA3 I148M and liver fat and fibrosis scores predict liver disease mortality in the United States population.
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.31032
Abstract: BACKGROUND AND AIMS Fatty liver causes premature death worldwide and requires long-term health care. We examined relationships of liver disease markers, including patatin-like phospholipase domain-containing protein 3 (PNPLA3) I148M, with mortality in the U.S. National… read more here.
Keywords: fibrosis; liver disease; mortality; liver fat ... See more keywords
Quantification of liver fat in the presence of iron overload
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Magnetic Resonance Imaging"
DOI: 10.1002/jmri.25382
Abstract: To evaluate the accuracy of R2* models (1/T2* = R2*) for chemical shift‐encoded magnetic resonance imaging (CSE‐MRI)‐based proton density fat‐fraction (PDFF) quantification in patients with fatty liver and iron overload, using MR spectroscopy (MRS) as… read more here.
Keywords: quantification liver; iron overload; fat presence; liver fat ... See more keywords
Interobserver Variability in Ultrasound‐Based Liver Fat Quantification
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Ultrasound in Medicine"
DOI: 10.1002/jum.16048
Abstract: To assess interobserver variability in ultrasound‐based quantitative liver fat content measurements and to determine how much time these quantitative ultrasound (QUS) techniques require. read more here.
Keywords: ultrasound based; interobserver variability; variability ultrasound; liver fat ... See more keywords
Free‐breathing liver fat quantification using a multiecho 3D stack‐of‐radial technique
Sign Up to like & getrecommendations! Published in 2018 at "Magnetic Resonance in Medicine"
DOI: 10.1002/mrm.26693
Abstract: The diagnostic gold standard for nonalcoholic fatty liver disease is an invasive biopsy. Noninvasive Cartesian MRI fat quantification remains limited to a breath‐hold (BH). In this work, a novel free‐breathing 3D stack‐of‐radial (FB radial) liver… read more here.
Keywords: free breathing; stack radial; liver fat; quantification ... See more keywords
Radiofrequency coil design for improving human liver fat quantification in a portable single‐side magnetic resonance system
Sign Up to like & getrecommendations! Published in 2022 at "NMR in Biomedicine"
DOI: 10.1002/nbm.4875
Abstract: Earlier diagnosis of nonalcoholic fatty liver disease (NAFLD) is important to prevent progression of the disease. Recently, a low‐cost portable magnetic resonance (MR) system was developed as a point‐of‐care screening tool for in vivo liver… read more here.
Keywords: coil design; liver fat; fat quantification; coil ... See more keywords
Characterization of hepatic fatty acids using Magnetic Resonance Spectroscopy for the assessment of treatment response to Metformin in an eNOS-/- mouse model of metabolic NAFLD-NASH.
Sign Up to like & getrecommendations! Published in 2023 at "NMR in biomedicine"
DOI: 10.1002/nbm.4932
Abstract: Non-Alcoholic Fatty Liver Disease (NAFLD) is the leading cause of chronic liver disease worldwide. Liver biopsy remains the gold-standard for diagnosis and staging of disease. There is a clinical need for non-invasive diagnostic tools for… read more here.
Keywords: magnetic resonance; liver fat; spectroscopy; treatment ... See more keywords
Metabolic profiling of liver fat—Limited insights by big data research so far
Sign Up to like & getrecommendations! Published in 2023 at "Obesity"
DOI: 10.1002/oby.23713
Abstract: In a study on a subgroup of the UK Biobank population in this issue of Obesity , the authors addressed the association of 180 blood metabolites (by nuclear magnetic resonance [NMR] spectrometry) with liver fat… read more here.
Keywords: liver; liver fat; fatty acids; density lipoprotein ... See more keywords
Branched-chain amino acid metabolism, insulin sensitivity and liver fat response to exercise training in sedentary dysglycaemic and normoglycaemic men
Sign Up to like & getrecommendations! Published in 2020 at "Diabetologia"
DOI: 10.1007/s00125-020-05296-0
Abstract: Aims/hypothesis Obesity and insulin resistance may be associated with elevated plasma concentration of branched-chain amino acids (BCAAs) and impaired BCAA metabolism. However, it is unknown whether the insulin-sensitising effect of long-term exercise can be explained… read more here.
Keywords: insulin; metabolism; normoglycaemic men; insulin sensitivity ... See more keywords
Metabolomics: a search for biomarkers of visceral fat and liver fat content
Sign Up to like & getrecommendations! Published in 2019 at "Metabolomics"
DOI: 10.1007/s11306-019-1599-x
Abstract: Excess visceral and liver fat are known risk factors for cardiometabolic disorders. Metabolomics might allow for easier quantification of these ectopic fat depots, instead of using invasive and costly tools such as MRI or approximations… read more here.
Keywords: visceral fat; liver fat; biomarkers visceral; content ... See more keywords
Design and rationale of the INSYTE study: A randomised, placebo controlled study to test the efficacy of a synbiotic on liver fat, disease biomarkers and intestinal microbiota in non-alcoholic fatty liver disease.
Sign Up to like & getrecommendations! Published in 2018 at "Contemporary clinical trials"
DOI: 10.1016/j.cct.2018.05.010
Abstract: BACKGROUND Non-alcoholic fatty liver disease (NAFLD) represents a spectrum of fat-related conditions ranging from simple fatty liver, to non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis. There is growing evidence that NAFLD is a multisystem disease, affecting… read more here.
Keywords: fatty liver; non alcoholic; study; disease ... See more keywords
Ratio of muscle mass to fat mass assessed by bioelectrical impedance analysis is significantly correlated with liver fat accumulation in patients with type 2 diabetes mellitus.
Sign Up to like & getrecommendations! Published in 2018 at "Diabetes research and clinical practice"
DOI: 10.1016/j.diabres.2018.02.009
Abstract: AIMS Obesity and ectopic fat accumulation are important conditions of type 2 diabetes mellitus (T2DM). Our aim was to determine whether bioelectrical impedance body composition analysis combined with blood test results could estimate liver ectopic… read more here.
Keywords: accumulation; fat accumulation; muscle; mass ... See more keywords