Restoration of Sinusoid Fenestrae Followed by Targeted Nanoassembly Delivery of an Anti‐Fibrotic Agent Improves Treatment Efficacy in Liver Fibrosis
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Materials"
DOI: 10.1002/adma.202212206
Abstract: During the onset of liver fibrosis, capillarized liver sinusoidal endothelial cells (LSECs) limit substance exchange between the blood and the Disse space, further accelerating hepatic stellate cell (HSCs) activation and fibrosis progression. Limited accessibility of… read more here.
Keywords: liver fibrosis; delivery anti; ignp jq1; treatment ... See more keywords
Scar‐Degrading Endothelial Cells as a Treatment for Advanced Liver Fibrosis
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DOI: 10.1002/advs.202203315
Abstract: Deposition of extracellular matrix (ECM) in the liver is an important feature of liver cirrhosis. Recovery from liver cirrhosis is physiologically challenging, partially due to the ECM in scar tissue showing resistance to cell‐mediated degradation… read more here.
Keywords: liver fibrosis; endothelial cells; degrading endothelial; advanced liver ... See more keywords
Peptide‐Based Nanoarchitectonics for the Treatment of Liver Fibrosis
Sign Up to like & getrecommendations! Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202300002
Abstract: Liver fibrosis is a process of excessive accumulation of extracellular matrix caused by liver injury. Liver fibrosis can progress to cirrhosis or even liver cancer without proper intervention. Until now, no effective therapeutic drugs have… read more here.
Keywords: peptide based; liver fibrosis; based nanoarchitectonics; nanoarchitectonics treatment ... See more keywords
Imatinib suppresses activation of hepatic stellate cells by targeting STAT3/IL‐6 pathway through miR‐124
Sign Up to like & getrecommendations! Published in 2023 at "Cell Biology International"
DOI: 10.1002/cbin.11992
Abstract: The activation of hepatic stellate cells is the primary function of facilitating liver fibrosis. Interfering with the coordinators of different signaling pathways in activated hepatic stellate cells (aHSCs) could be a potential approach in ameliorating… read more here.
Keywords: imatinib; liver fibrosis; mir 124; stat3 ... See more keywords
Lower eGFR is associated with increased probability of liver fibrosis in Chinese diabetic patients
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes/Metabolism Research and Reviews"
DOI: 10.1002/dmrr.3294
Abstract: Kidney dysfunction is linked to nonalcoholic fatty liver disease (NAFLD) progression including fibrosis, steatosis, or inflammation. We aimed to explore whether lower levels of estimated glomerular filtration rate (eGFR) was associated with increased probability of… read more here.
Keywords: egfr associated; liver fibrosis; probability liver; associated increased ... See more keywords
Low 25 (OH) vitamin D levels are associated with increased prevalence of NAFLD and significant liver fibrosis.
Sign Up to like & getrecommendations! Published in 2023 at "Diabetes/metabolism research and reviews"
DOI: 10.1002/dmrr.3628
Abstract: AIMS Evidence on the role of 25-Hydroxyvitamin D (25(OH)D) in occurrence and progression of nonalcoholic fatty liver disease (NAFLD) is conflicting and population based-data are scarce. Here, we assess the association between 25(OH)D levels, NAFLD… read more here.
Keywords: liver fibrosis; prevalence nafld; vitamin; fibrosis ... See more keywords
Prognostic value of the liver fibrosis marker fibrosis‐5 index in patients with acute heart failure
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DOI: 10.1002/ehf2.13829
Abstract: Recently, liver fibrosis markers, such as the fibrosis‐4 index (FIB‐4), have been shown to be associated with prognosis in patients with heart failure. The fibrosis‐5 (FIB‐5) index, which assesses albumin, alkaline phosphatase, aspartate transaminase, alanine… read more here.
Keywords: liver fibrosis; fibrosis; index; heart failure ... See more keywords
Comparison of liver fibrosis scores for predicting mortality and morbidity in heart failure with preserved ejection fraction
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DOI: 10.1002/ehf2.14336
Abstract: Liver fibrosis scores (LFSs) are non‐invasive and effective tools for estimating cardiovascular risks. To better understand the advantages and limitations of currently available LFSs, we determined to compare the predictive values of LFSs in heart… read more here.
Keywords: heart failure; liver fibrosis; fibrosis scores; failure preserved ... See more keywords
Hepatocyte autotaxin expression promotes liver fibrosis and cancer
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DOI: 10.1002/hep.28973
Abstract: Autotaxin (ATX) is a secreted lysophospholipase D that catalyzes the production of lysophosphatidic acid (LPA), a pleiotropic growth‐factor–like lysophospholipid. Increased ATX expression has been detected in various chronic inflammatory disorders and different types of cancer;… read more here.
Keywords: atx; liver fibrosis; fibrosis cancer; expression ... See more keywords
Cholangiocyte‐Derived Exosomal Long Noncoding RNA H19 Promotes Hepatic Stellate Cell Activation and Cholestatic Liver Fibrosis
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DOI: 10.1002/hep.30662
Abstract: Activation of hepatic stellate cells (HSCs) represents the primary driving force to promote the progression of chronic cholestatic liver diseases. We previously reported that cholangiocyte‐derived exosomal long noncoding RNA‐H19 (lncRNA‐H19) plays a critical role in… read more here.
Keywords: liver fibrosis; liver; cholangiocyte derived; activation ... See more keywords
A Deactivation Factor of Fibrogenic Hepatic Stellate Cells Induces Regression of Liver Fibrosis in Mice
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30965
Abstract: Hepatic stellate cells (HSCs), a key player in the progression of liver fibrosis, are activated by various inflammatory stimuli and converted to myofibroblast‐like cells with excessive collagen production. Despite many attempts to suppress activation of… read more here.
Keywords: fibrosis; liver fibrosis; deactivation; hepatic stellate ... See more keywords