Removing the FDA’s Boxed Hepatotoxicity Warning and Liver Function Testing Requirement for Ambrisentan
Sign Up to like & getrecommendations! Published in 2024 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2024.19873
Abstract: Key Points Question How did use of and liver function tests (LFTs) for ambrisentan vs bosentan change after the boxed hepatotoxicity warning and LFT requirement under the risk evaluation and mitigation strategy (REMS) were removed… read more here.
Keywords: liver function; boxed hepatotoxicity; hepatotoxicity warning; ambrisentan bosentan ... See more keywords
MoS2 Nanozyme–Chlorella Hydrogels: Pioneering a Hepatocellular Carcinoma Integrative Therapy
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202417125
Abstract: Hepatocellular carcinoma (HCC) poses a formidable challenge to global health, and surgical resection is the predominant therapeutic strategy. However, the efficacy of postoperative adjuvant treatments is often compromised by the need to preserve liver function.… read more here.
Keywords: chlorella hydrogels; carcinoma; nanozyme chlorella; mos2 nanozyme ... See more keywords
Pharmacokinetics and Pharmacodynamics of Ursodeoxycholic Acid in an Overweight Population With Abnormal Liver Function
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.790
Abstract: Ursodeoxycholic acid (UDCA) is a secondary bile acid that is used to treat primary biliary cholangitis. Although UDCA has a hepatoprotective effect in some diseases, its benefit in nonalcoholic fatty liver disease (NAFLD) remains controversial.… read more here.
Keywords: liver function; udca 300; ursodeoxycholic acid; twice daily ... See more keywords
Recommendations for the Evaluation for Autoimmune Liver Disease in Nonalcoholic Fatty Liver Disease
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.30057
Abstract: We read with interest the article published by Chalisani et al.(1) These Guidelines provide clarity for the diagnosis and management of NAFLD. However, we feel that routine diagnosis of nonalcoholic fatty liver disease (NAFLD) can… read more here.
Keywords: liver function; fatty liver; hepatitis; disease ... See more keywords
Establishment of age‐ and sex‐specific reference intervals for serum liver function tests in pediatric population aged 1–
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.23708
Abstract: The diagnosis, treatment, and prognosis of pediatric diseases rely on the accurate establishment of the reference interval (RI). This study aimed to establish pediatric RIs for liver function tests and evaluated the correlation of the… read more here.
Keywords: liver function; establishment; study; reference ... See more keywords
Liver function test abnormalities in a longitudinal cohort of Thai individuals treated since acute HIV infection
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the International AIDS Society"
DOI: 10.1002/jia2.25444
Abstract: Liver disease is a common cause of non‐AIDS morbidity and mortality in people living with HIV (PLHIV), but the prevalence and significance of liver function test (LFT) abnormalities in early HIV infection is unknown. This… read more here.
Keywords: hiv infection; liver function; function test; infection ... See more keywords
The effect of (Cornus mas L.) fruit extract on liver function among patients with nonalcoholic fatty liver: A double‐blind randomized clinical trial
Sign Up to like & getrecommendations! Published in 2021 at "Phytotherapy Research"
DOI: 10.1002/ptr.7199
Abstract: This double‐blind randomized clinical trial aimed to investigate impact of Cornus mas L. fruit extract (CMFE) on liver function in nonalcoholic fatty liver disease (NAFLD). Fifty patients were randomly assigned into the CMFE and placebo… read more here.
Keywords: liver function; placebo; blind randomized; randomized clinical ... See more keywords
Licorice and liver function in patients with primary liver disease: A systematic review and meta‐analysis of RCTs
Sign Up to like & getrecommendations! Published in 2024 at "Phytotherapy Research"
DOI: 10.1002/ptr.8288
Abstract: Licorice (Glycyrrhiza spp.) has been a cornerstone of traditional Chinese and Japanese medicine. This systematic review and meta‐analysis aimed to evaluate the efficacy of licorice formulations, alone or in combination with other herbs, on liver… read more here.
Keywords: systematic review; analysis; review meta; liver function ... See more keywords
T1 mapping for liver function evaluation in gadoxetic acid–enhanced MR imaging: comparison of look-locker inversion recovery and B1 inhomogeneity–corrected variable flip angle method
Sign Up to like & getrecommendations! Published in 2019 at "European Radiology"
DOI: 10.1007/s00330-018-5947-4
Abstract: ObjectivesTo compare look-locker inversion recovery (LLIR) and B1 inhomogeneity–corrected variable flip angle T1 mapping methods for estimation of liver function and prediction of hepatic insufficiency and decompensation on gadoxetic acid–enhanced MR imaging.MethodsIn this retrospective study,… read more here.
Keywords: hbp; liver function; t1liver post; post ... See more keywords
Exposure to benzotriazoles and benzothiazoles in Czech male population and its associations with biomarkers of liver function, serum lipids and oxidative stress
Sign Up to like & getrecommendations! Published in 2024 at "International Archives of Occupational and Environmental Health"
DOI: 10.1007/s00420-024-02059-x
Abstract: Benzotriazoles and benzothiazoles (BTs) are high-production volume chemicals as well as widely distributed emerging pollutants with potential health risk. However, information about human exposure to BTs and associated health outcomes is limited. We aimed to… read more here.
Keywords: oxidative stress; function serum; serum lipids; liver function ... See more keywords
Prospective Assessment of Liver Function by an Enzymatic Liver Function Test to Estimate Short-Term Survival in Patients with Liver Cirrhosis
Sign Up to like & getrecommendations! Published in 2018 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-018-5360-5
Abstract: BackgroundMELD attempts to objectively predict the risk of mortality of patients with liver cirrhosis and is commonly used to prioritize organ allocation. Despite the usefulness of the MELD, updated metrics could further improve the accuracy… read more here.
Keywords: liver function; liver cirrhosis; function; short term ... See more keywords