Influence of intranasal exposure of MPTP in multiple doses on liver functions and transition from non-motor to motor symptoms in a rat PD model
Sign Up to like & getrecommendations! Published in 2019 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-019-01715-1
Abstract: Besides the effects on the striatum, the impairment of visceral organs including liver functions has been reported in Parkinson’s disease (PD) patients. However, it is yet unclear if liver functions are affected in the early… read more here.
Keywords: mptp; liver functions; non motor; exposure mptp ... See more keywords
Human induced pluripotent stem cell-derived hepatocytes and their culturing methods to maintain liver functions for pharmacokinetics and safety evaluation of pharmaceuticals.
Sign Up to like & getrecommendations! Published in 2020 at "Current pharmaceutical biotechnology"
DOI: 10.2174/1389201021666200131123524
Abstract: Human hepatocytes are very important cell types for pharmacokinetics and the safety evaluation of pharmaceuticals. However, widely used primary hepatocytes with individual variations in liver function lose those functions rapidly in culture. Hepatic cell lines… read more here.
Keywords: evaluation pharmaceuticals; liver functions; safety evaluation; pharmacokinetics safety ... See more keywords