Stearoyl-CoA desaturase regulates sorafenib resistance via modulation of ER stress-induced differentiation.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2017.06.015
Abstract: BACKGROUND & AIMS We investigated the functional role and clinical significance of stearoyl-CoA desaturase-1 (SCD1) mediated endoplasmic reticulum (ER) stress in regulating liver tumor-initiating cells (T-ICs) and sorafenib resistance, with the aim of developing a… read more here.
Keywords: scd1; liver ics; stress; sorafenib resistance ... See more keywords
microRNA-29a regulates liver tumor-initiating cells expansion via Bcl-2 pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2019.111781
Abstract: MicroRNAs (miRNAs) participate in tumorigenesis, progression, recurrence and drug resistance of hepatocellular carcinoma (HCC). However, few miRNAs have been identified and entered clinical practice. Herein, we report that miR-29a is downregulated in tumor-initiating cells (T-ICs)… read more here.
Keywords: mir 29a; expansion; tumor initiating; initiating cells ... See more keywords