Water Specific MRI T1 Mapping for Evaluating Liver Inflammation Activity Grades in Rats With Methionine‐Choline‐Deficient Diet‐Induced Nonalcoholic Fatty Liver Disease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Magnetic Resonance Imaging"
DOI: 10.1002/jmri.28131
Abstract: Early detection and grading of liver inflammation are important for the management of nonalcoholic fatty liver disease (NAFLD) patients. There is still lack of a noninvasive way for the inflammation characterization in NAFLD. read more here.
Keywords: nonalcoholic fatty; inflammation; fatty liver; liver inflammation ... See more keywords
Mediators of liver inflammation and carcinogenesis
Sign Up to like & getrecommendations! Published in 2021 at "Seminars in Immunopathology"
DOI: 10.1007/s00281-021-00880-x
Abstract: The present issue of Seminars in Immunopathology covers a number of reviews that summarize emerging concepts, potential therapeutic targets and mechanisms that underly the immunopathology of liver inflammation and liver cancer. Liver inflammation is one… read more here.
Keywords: liver inflammation; immunopathology; liver cancer;
OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.01.028
Abstract: Inflammatory signaling pathways are tightly regulated to avoid chronic inflammation and the development of disease. OTULIN is a deubiquitinating enzyme that controls inflammation by cleaving linear ubiquitin chains generated by the linear ubiquitin chain assembly… read more here.
Keywords: hepatocellular carcinoma; kinase; inflammation; liver inflammation ... See more keywords
Elevated interleukin‐35 suppresses liver inflammation by regulation of T helper 17 cells in acute hepatitis B virus infection
Sign Up to like & getrecommendations! Published in 2019 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2019.02.048
Abstract: Abstract Interleukin (IL)‐35 is a responsive anti‐inflammatory cytokine implicated in different diseases processes. It has been reported that elevated IL‐35 contributed to immunosuppression in chronic hepatitis by modulation of T helper 17 (Th17) and regulatory… read more here.
Keywords: liver inflammation; hbv; th17 cells; acute hepatitis ... See more keywords
Thioridazine aggravates skeletal myositis, systemic and liver inflammation in Trypanosoma cruzi-infected and benznidazole-treated mice.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106611
Abstract: While thioridazine (Tio) inhibits the antioxidant defenses of Trypanosoma cruzi, the gold standard antitrypanosomal drug benznidazole (Bz) has potent anti-inflammatory and pro-oxidant properties. The combination of these drugs has never been tested to determine the… read more here.
Keywords: tio; liver inflammation; cruzi; myositis ... See more keywords
A novel diagnostic algorithm to predict significant liver inflammation in chronic hepatitis B virus infection patients with detectable HBV DNA and persistently normal alanine transaminase
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-33412-z
Abstract: Significant liver inflammation might be found in 20–34% of chronic hepatitis B virus (HBV) infection patients with detectable HBV DNA and persistently normal alanine transaminase (ALT) (PNALT). We aimed to develop a diagnostic algorithm to… read more here.
Keywords: liver inflammation; significant liver; infection patients; patients detectable ... See more keywords
Intra-Hepatic Depletion of Mucosal-Associated Invariant T Cells in Hepatitis C Virus-Induced Liver Inflammation.
Sign Up to like & getrecommendations! Published in 2017 at "Gastroenterology"
DOI: 10.1053/j.gastro.2017.07.043
Abstract: BACKGROUND & AIMS Chronic hepatitis affects phenotypes of innate and adaptive immune cells. Mucosal-associated invariant T (MAIT) cells are enriched in the liver as compared with the blood, respond to intra-hepatic cytokines, and (via the… read more here.
Keywords: mait cells; mait; liver inflammation; blood ... See more keywords
Selective bromodomain and extra-terminal bromodomain inhibitor inactivates macrophages and hepatic stellate cells to inhibit liver inflammation and fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2066756
Abstract: ABSTRACT Liver fibrosis occurs following inflammation triggered by the integrated actions of activated liver-resident macrophages (Kupffer cells) and hepatic stellate cells (HSCs), and the multiplicity of these mechanisms complicates drug therapy. Here, we demonstrate that… read more here.
Keywords: stellate cells; inflammation; bromodomain; liver inflammation ... See more keywords
Alcohol-induced extracellular asc specks perpetuate liver inflammation and damage in alcoholic hepatitis even after alcohol cessation.
Sign Up to like & getrecommendations! Published in 2023 at "Hepatology"
DOI: 10.1097/hep.0000000000000298
Abstract: BACKGROUND AIMS Prolonged systemic inflammation contributes to poor clinical outcomes in severe alcohol-associated hepatitis (AH) even after cessation of alcohol use. However, mechanisms leading to this persistent inflammation remain to be understood. APPROACH RESULTS We… read more here.
Keywords: alcohol; liver inflammation; alcohol induced; asc specks ... See more keywords
Persistent liver inflammation in chronic hepatitis C patients with advanced fibrosis after direct-acting antivirals induced sustained virological response
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the Chinese Medical Association"
DOI: 10.1097/jcma.0000000000000517
Abstract: Background: Direct-acting antivirals (DAA) improve sustained virological response (SVR) rates with normalization of liver enzymes in patients with hepatitis C. However, liver inflammation may persist despite virus eradication. We aimed to investigate the rate and… read more here.
Keywords: patients advanced; liver inflammation; persistent liver; advanced fibrosis ... See more keywords
The Proinflammatory Cytokines IL-18, IL-21, and IFN-γ Differentially Regulate Liver Inflammation and Anti-Mitochondrial Antibody Level in a Murine Model of Primary Biliary Cholangitis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Immunology Research"
DOI: 10.1155/2022/7111445
Abstract: Primary biliary cholangitis (PBC) is a cholestatic liver disease primarily featured by autoimmune-mediated damage of intrahepatic small- and medium-sized bile ducts. Elevated serum proinflammatory cytokines, serum anti-mitochondrial antibodies (AMAs), liver inflammation, and fibrosis are also… read more here.
Keywords: proinflammatory cytokines; liver inflammation; cholangitis;