Association of Prenatal Exposure to Endocrine-Disrupting Chemicals With Liver Injury in Children
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.20176
Abstract: Key Points Question Is prenatal exposure to endocrine-disrupting chemicals (EDCs) associated with liver injury and hepatocellular apoptosis in school-aged children? Findings In the Human Early-Life Exposome population-based cohort study of 1108 mother-child pairs from 6… read more here.
Keywords: liver injury; exposure endocrine; prenatal exposure; disrupting chemicals ... See more keywords
A literature review for the mechanisms of stress‐induced liver injury
Sign Up to like & getrecommendations! Published in 2019 at "Brain and Behavior"
DOI: 10.1002/brb3.1235
Abstract: Experimental studies and clinical observations have shown that stress can damage hepatic tissue both directly and indirectly. Many studies have partially revealed the contributors of stress‐induced liver injury; however, the whole process has not yet… read more here.
Keywords: induced liver; stress induced; liver injury; literature review ... See more keywords
Ketoconazole and Liver Injury: A Five‐Year Update
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.652
Abstract: Five years have passed since the Food and Drug Administration (FDA) issued its directives restricting the use of ketoconazole as an antifungal agent in clinical practice, and discouraging the use of ketoconazole as an index… read more here.
Keywords: drug; ketoconazole liver; year; liver injury ... See more keywords
Lymphocyte profile and immune checkpoint expression in drug-induced liver injury: an immunophenotyping study.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2423
Abstract: The identification of specific human leukocyte antigen (HLA) risk alleles in drug-induced liver injury (DILI) points towards an important role of the adaptive immune system in DILI development. In this study we aimed to corroborate… read more here.
Keywords: immune checkpoint; induced liver; drug induced; liver injury ... See more keywords
Oridonin ameliorates acetaminophen‐induced acute liver injury through ATF4/PGC‐1α pathway
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.22024
Abstract: Acetaminophen (APAP) overdose‐induced acute liver injury (ALI) causes hepatocyte cell death, oxidative stress, and inflammation. Oridonin (Ori), a covalent NLRP3‐inflammasome inhibitor, ameliorates APAP‐induced ALI through an unclear molecular mechanism. This study found that Ori decreased… read more here.
Keywords: apap; atf4 pgc; liver injury; acute liver ... See more keywords
Liver injury from herbal and dietary supplements
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology"
DOI: 10.1002/hep.28813
Abstract: Herbal and dietary supplements (HDS) are used increasingly both in the United States and worldwide, and HDS‐induced liver injury in the United States has increased proportionally. Current challenges in the diagnosis and management of HDS‐induced… read more here.
Keywords: dietary supplements; hds; herbal dietary; liver injury ... See more keywords
Forkhead box A2 regulates biliary heterogeneity and senescence during cholestatic liver injury in mice ‡
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology"
DOI: 10.1002/hep.28831
Abstract: Biliary‐committed progenitor cells (small mouse cholangiocytes; SMCCs) from small bile ducts are more resistant to hepatobiliary injury than large mouse cholangiocytes (LGCCs) from large bile ducts. The definitive endoderm marker, forkhead box A2 (FoxA2), is… read more here.
Keywords: cholestatic liver; senescence; liver; liver injury ... See more keywords
Clinical presentations and outcomes of bile duct loss caused by drugs and herbal and dietary supplements
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology"
DOI: 10.1002/hep.28967
Abstract: Bile duct loss during the course of drug‐induced liver injury is uncommon, but can be an indication of vanishing bile duct syndrome (VBDS). In this work, we assess the frequency, causes, clinical features, and outcomes… read more here.
Keywords: duct loss; duct; bile duct; liver injury ... See more keywords
Cholangiocyte‐derived exosomal long noncoding RNA H19 promotes cholestatic liver injury in mouse and humans
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DOI: 10.1002/hep.29838
Abstract: Cholestatic liver injury is an important clinical problem with limited understanding of disease pathologies. Exosomes are small extracellular vesicles released by a variety of cells, including cholangiocytes. Exosome‐mediated cell‐cell communication can modulate various cellular functions… read more here.
Keywords: cholestatic liver; hepatology; cholangiocyte derived; liver injury ... See more keywords
DEP domain–containing mTOR–interacting protein suppresses lipogenesis and ameliorates hepatic steatosis and acute‐on‐chronic liver injury in alcoholic liver disease
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.29849
Abstract: Alcoholic liver disease (ALD) is characterized by lipid accumulation and liver injury. However, how chronic alcohol consumption causes hepatic lipid accumulation remains elusive. The present study demonstrates that activation of the mechanistic target of rapamycin… read more here.
Keywords: liver; mtorc1; mtor; liver injury ... See more keywords
A Case of Immune‐Mediated Liver Injury Induced by Olaparib
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.30119
Abstract: Immune-mediated drug-induced liver injury (IM-DILI) can be triggered by biologic agents, in addition to traditional drugs, including statins, minocycline, and nitrofurantoin. IM-DILI may be indistinguishable at presentation from autoimmune hepatitis (AIH) and cessation of the… read more here.
Keywords: case immune; injury induced; immune mediated; liver injury ... See more keywords