Differences of first-pass effect in the liver and intestine contribute to the stereoselective pharmacokinetics of rhynchophylline and isorhynchophylline epimers in rats.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2017.07.039
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Uncaria rhynchophylla (Miq.) Miq. ex Havil., is a plant species used in traditional Chinese medicine to treat cardiovascular and central nervous system diseases. Rhynchophylline (RIN) and isorhynchophylline (IRN), a pair of epimers, are… read more here.
Keywords: liver intestine; differences first; first pass; stereoselective pharmacokinetics ... See more keywords
Comparison of mouse and human cytochrome P450 mediated-drug metabolising activities in hepatic and extrahepatic microsomes
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DOI: 10.1080/00498254.2022.2066581
Abstract: Abstract Despite the importance of mice as a preclinical species in drug testing, their hepatic and extrahepatic drug-metabolising characteristics are poorly understood. Here, we compared the P450-dependent drug oxidation activity in tissue microsomes and distribution… read more here.
Keywords: drug metabolising; liver intestine; hydroxylation; humans mice ... See more keywords
Retrospective study of pathology-based investigative techniques for the assessment of diet-induced changes in liver and intestine of flatfish
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DOI: 10.1080/1828051x.2017.1364610
Abstract: Abstract This article proposes a systematic evaluation of methods pertaining to the pathology discipline (histology, histochemistry, ultrastructure, in situ techniques, image analysis including morphometry and fractal dimension analysis) employed to study liver and intestine status… read more here.
Keywords: liver intestine; pathology; cell; retrospective study ... See more keywords
P-70: Native Jejunal Conduit for Urinary Diversion in Enbloc Liver-Intestine-Kidney Transplantation for a Patient with Irradiation Enteritis and Cystitis
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DOI: 10.1097/01.tp.0000758084.76069.33
Abstract: Background: Recipients requiring kidney-enbloc visceral allograft often face challenges during transplantation. We report a case with a unique technique of urinary diversion in enbloc liver-intestine-kidney transplantation for irradiation enteritis and cystitis. Methods: The patient is… read more here.
Keywords: liver intestine; allograft; transplantation; urinary diversion ... See more keywords
Economic Impact of European Liver and Intestine Transplantation Association (ELITA) Recommendations for Hepatitis B Prophylaxis After Liver Transplantation
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DOI: 10.3389/ti.2023.10954
Abstract: The European Liver and Intestine Transplant Association, ELITA, promoted a Consensus Conference involving 20 experts across the world which generated updated guidelines on HBV prophylaxis in liver transplant candidates and recipients. This study explores the… read more here.
Keywords: liver; european liver; liver intestine; prophylaxis liver ... See more keywords