Proton pump inhibition for secondary hemochromatosis in hereditary anemia: a phase III placebo‐controlled randomized cross‐over clinical trial
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26581
Abstract: Iron overload is a severe general complication of hereditary anemias. Treatment with iron chelators is hampered by important side‐effects, high costs, and the lack of availability in many countries with a high prevalence of hereditary… read more here.
Keywords: iron content; iron; trial; placebo ... See more keywords
Improving CPMG liver iron estimates with a T 1 -corrected proton density estimator.
Sign Up to like & getrecommendations! Published in 2021 at "Magnetic resonance in medicine"
DOI: 10.1002/mrm.28943
Abstract: PURPOSE CPMG spin echo acquisitions are attractive for diagnosing and monitoring liver iron concentration in iron overload disorders due to their time efficiency and potential to reveal unique information about tissue iron distribution. Clinical adoption… read more here.
Keywords: liver iron; iron; cpmg; proton density ... See more keywords
Liver iron quantification in children and young adults: comparison of a volumetric multi-echo 3-D Dixon sequence with conventional 2-D T2* relaxometry
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric Radiology"
DOI: 10.1007/s00247-022-05352-4
Abstract: Magnetic resonance imaging (MRI)-based liver iron quantification is the standard of care to guide chelation therapy in children at risk of hemochromatosis. T2* relaxometry is the most widely used technique but requires third-party software for… read more here.
Keywords: multi echo; liver iron; relaxometry; echo dixon ... See more keywords
From the bottom of the heart: Measuring liver iron concentration on cardiac MRI.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical imaging"
DOI: 10.1016/j.clinimag.2017.09.008
Abstract: Patients with hemochromatosis require regular surveillance of liver and cardiac iron concentration with liver and cardiac MRI. However, cardiac MRI includes a part of the liver in the field of view. The purpose of this… read more here.
Keywords: liver; liver iron; mri; iron concentration ... See more keywords
R2 and R2* MRI assessment of liver iron content in an undifferentiated diagnostic population with hyperferritinaemia, and impact on clinical decision making.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of radiology"
DOI: 10.1016/j.ejrad.2020.109473
Abstract: PURPOSE To confirm the linear correlation between Ferriscan® R2 (1/T2 Relaxomatry) and R2* (1/T2* Relaxometry) derived 3D Gradient echo (GRE) mDIXON-Quant sequence (Philips) with simultaneous production of a proton density fat fraction (PDFF) in undifferentiated… read more here.
Keywords: clinical decision; iron content; liver iron; decision making ... See more keywords
MRI for the measurement of liver iron content, and for the diagnosis and follow-up of iron overload disorders.
Sign Up to like & getrecommendations! Published in 2017 at "Presse medicale"
DOI: 10.1016/j.lpm.2017.10.008
Abstract: MRI is now the reference method for detecting and quantifying hepatic and extrahepatic iron overload, regardless of its cause. The decrease of the hepatic signal is proportional to the amount of iron in the tissues.… read more here.
Keywords: measurement liver; mri measurement; liver iron; iron overload ... See more keywords
Value of liver iron concentration in healthy volunteers assessed by MRI
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-74968-z
Abstract: Iron overload is a relatively common clinical condition resulting from disorders such as hereditary hemochromatosis, thalassemia, sickle cell disease, and myelodysplasia that can lead to progressive fibrosis and eventually cirrhosis of the liver. Therefore, it… read more here.
Keywords: value; liver; liver iron; concentration ... See more keywords
Prediction of Heart and Liver Iron Overload in β-Thalassemia Major Patients Using Machine Learning Methods
Sign Up to like & getrecommendations! Published in 2022 at "Hemoglobin"
DOI: 10.1080/03630269.2022.2158100
Abstract: Abstract Patients with β-thalassemia major (β-TM) face a wide range of complications as a result of excess iron in vital organs, including the heart and liver. Our aim was to find the best predictive machine… read more here.
Keywords: heart liver; liver iron; iron; iron overload ... See more keywords
The role of diffusion‐weighted imaging in prediction liver iron concentration in beta‐thalassaemia patients
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Medical Imaging and Radiation Oncology"
DOI: 10.1111/1754-9485.12639
Abstract: OBJECTIVE The aim of this study was to analyse the value of diffusion-weighted magnetic resonance imaging (DWI) to determine the liver parenchyma iron concentration in β-thalassaemia major patients. METHODS Abdominal magnetic resonance (MR) imaging, including… read more here.
Keywords: diffusion; liver iron; diffusion weighted; iron ... See more keywords
Longitudinal changes in LIC and other parameters in patients receiving different chelation regimens: Data from LICNET
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Haematology"
DOI: 10.1111/ejh.12989
Abstract: The liver remains the primary site of iron storage, with liver iron concentration (LIC) being a strong surrogate of total body iron. MRI‐R2 can accurately measure LIC. The LICNET (Liver Iron Cutino Network) was established… read more here.
Keywords: longitudinal changes; liver iron; different chelation; iron ... See more keywords
Quantification of Liver Iron Overload with MRI: Review and Guidelines from the ESGAR and SAR.
Sign Up to like & getrecommendations! Published in 2023 at "Radiology"
DOI: 10.1148/radiol.221856
Abstract: Accumulation of excess iron in the body, or systemic iron overload, results from a variety of causes. The concentration of iron in the liver is linearly related to the total body iron stores and, for… read more here.
Keywords: liver iron; iron; iron overload; quantification liver ... See more keywords