The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial‐mesenchymal transition
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30975
Abstract: The liver kinase B1 (LKB1) controls cellular metabolism and cell polarity across species. We previously established a mechanism for negative regulation of transforming growth factor β (TGFβ) signaling by LKB1. The impact of this mechanism… read more here.
Keywords: morphogenesis; mediate epithelial; kinase; liver kinase ... See more keywords
Liver Kinase B1 Links Macrophage Metabolism Sensing and Atherosclerosis.
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DOI: 10.1161/circresaha.117.311923
Abstract: Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of cholesterol-laden macrophages at susceptible sites in the artery wall. Altered cellular metabolism plays an important role in the conversion of a macrophage into a… read more here.
Keywords: links macrophage; metabolism sensing; liver kinase; macrophage ... See more keywords
Loss of liver kinase B1 in human seminoma
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1081110
Abstract: Testicular cancer is a common malignancy of young males and is believed to be originated from defective embryonic or adult germ cells. Liver kinase B1 (LKB1) is a serine/threonine kinase and a tumor suppressor gene.… read more here.
Keywords: seminoma; human seminoma; liver kinase; lkb1 ... See more keywords
Prognostic Value of Liver Kinase B1 (LKB1) in Gastric Cancer-Associated Tumor Microenvironment Immunity
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DOI: 10.3390/biomedicines11030688
Abstract: Liver kinase B1 (LKB1) is a tumor suppressor gene, the inactivation of which occurs frequently in different tumor types. However, whether LKB1 is associated with the clinical features of gastric cancer (GC) and regulating tumor… read more here.
Keywords: cd3 cd8; liver kinase; kinase lkb1; gastric cancer ... See more keywords
Liver kinase B1 in exosomes inhibits immune checkpoint programmed death ligand 1 and metastatic progression of intrahepatic cholangiocarcinoma
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DOI: 10.3892/or.2022.8367
Abstract: The increasing morbidity and high mortality of intrahepatic cholangiocarcinoma (ICC) has led to the urgent need for new diagnostics and therapeutics. Liver kinase B1 (LKB1) exerts a tumor suppressor role in multiple malignances, while its… read more here.
Keywords: intrahepatic cholangiocarcinoma; immune checkpoint; exosomal lkb1; icc cells ... See more keywords