Targeting hepatic macrophages to treat liver diseases.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2017.02.026
Abstract: Our view on liver macrophages in the context of health and disease has been reformed by the recognition of a remarkable heterogeneity of phagocytes in the liver. Liver macrophages consist of ontogenically distinct populations termed… read more here.
Keywords: liver diseases; treat liver; liver; liver macrophages ... See more keywords
The amino acid sensor GCN2 controls red blood cell clearance and iron metabolism through regulation of liver macrophages
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2121251119
Abstract: Significance In this study, we define a regulatory pathway controlling tissue-resident macrophages during stress through the translational control of a subset of messenger RNAs (mRNAs) and transcriptional reprogramming. Our data reveal that the GCN2-eIF2α pathway… read more here.
Keywords: clearance; gcn2; red blood; liver macrophages ... See more keywords
Liver macrophages: Friend or foe during hepatitis B infection?
Sign Up to like & getrecommendations! Published in 2018 at "Liver International"
DOI: 10.1111/liv.13884
Abstract: The Hepatitis B virus chronically infects the liver of 250 million people worldwide. Over the past decades, major advances have been made in the understanding of Hepatitis B virus life cycle in hepatocytes. Beside these… read more here.
Keywords: hbv infection; liver macrophages; hepatitis virus; liver ... See more keywords
STING Induces Liver Ischemia-Reperfusion Injury by Promoting Calcium-Dependent Caspase 1-GSDMD Processing in Macrophages
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/8123157
Abstract: Objectives Although a recent study reported that stimulator of interferon genes (STING) in macrophages has an important regulatory effect on liver ischemia-reperfusion injury (IRI), the underlying mechanism of STING-dependent innate immune activation in liver macrophages… read more here.
Keywords: calcium; liver; caspase gsdmd; microscopy ... See more keywords
In Vivo and In Vitro Characterization of Primary Human Liver Macrophages and Their Inflammatory State
Sign Up to like & getrecommendations! Published in 2021 at "Biomedicines"
DOI: 10.3390/biomedicines9040406
Abstract: Liver macrophages (LMs) play a central role in acute and chronic liver pathologies. Investigation of these processes in humans as well as the development of diagnostic tools and new therapeutic strategies require in vitro models… read more here.
Keywords: vivo vitro; vitro characterization; liver; liver macrophages ... See more keywords
Fetuin-A in Activated Liver Macrophages Is a Key Feature of Non-Alcoholic Steatohepatitis
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo12070625
Abstract: Fetuin-A, a plasma multifunctional protein known to play a role in insulin resistance, is usually presented as a liver secreted protein. However, fetuin-A adipose tissue production has been also described. Here, we evaluated fetuin-A production… read more here.
Keywords: alcoholic steatohepatitis; non alcoholic; fetuin; liver macrophages ... See more keywords