Patient‐Derived Organoids from Colorectal Cancer with Paired Liver Metastasis Reveal Tumor Heterogeneity and Predict Response to Chemotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202204097
Abstract: There is no effective method to predict chemotherapy response and postoperative prognosis of colorectal cancer liver metastasis (CRLM) patients. Patient‐derived organoid (PDO) has become an important preclinical model. Herein, a living biobank with 50 CRLM… read more here.
Keywords: colorectal cancer; patient derived; liver metastasis; paired liver ... See more keywords
Anlotinib for patients with small cell lung cancer and baseline liver metastases: A post hoc analysis of the ALTER 1202 trial
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Medicine"
DOI: 10.1002/cam4.4507
Abstract: Liver metastasis is common in advanced small cell lung cancer (SCLC). There is no evidence‐proven treatment beyond the second line in patients with SCLC and liver metastasis. This study aimed to investigate survival in patients… read more here.
Keywords: cancer; group; placebo; baseline ... See more keywords
Outcomes of simultaneous resection for elderly patients with colorectal liver metastasis: A propensity score matching analysis
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DOI: 10.1002/cam4.4826
Abstract: Evidence on simultaneous resection for elderly patients (age ≥ 70 years) with colorectal liver metastasis (CRLM) is lacking. read more here.
Keywords: simultaneous resection; elderly patients; resection elderly; liver metastasis ... See more keywords
NOD‐like receptor C4 Inflammasome Regulates the Growth of Colon Cancer Liver Metastasis in NAFLD
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DOI: 10.1002/hep.30693
Abstract: Nonalcoholic fatty liver disease (NAFLD) enhances the growth and recurrence of colorectal cancer (CRC) liver metastasis. With the rising prevalence of NAFLD, a better understanding of the molecular mechanism underlying NAFLD‐associated liver metastasis is crucial.… read more here.
Keywords: tumor growth; growth; liver metastasis; liver ... See more keywords
Patients with colorectal cancer and brain metastasis: The relevance of extracranial metastatic patterns predicting time intervals to first occurrence of intracranial metastasis and survival
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Cancer"
DOI: 10.1002/ijc.33364
Abstract: The aim of the study was to investigate the predictive impact of extracranial metastatic patterns on course of disease and survival in patients with colorectal cancer (CRC) and brain metastasis (BM). A total of 228… read more here.
Keywords: extracranial metastatic; metastatic patterns; metastasis; liver metastasis ... See more keywords
Highly‐metastatic colorectal cancer cell released miR‐181a‐5p‐rich extracellular vesicles promote liver metastasis by activating hepatic stellate cells and remodelling the tumour microenvironment
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12186
Abstract: Abstract Liver metastasis of colorectal cancer (CRLM) is the most common cause of CRC‐related mortality, and is typically caused by interactions between CRC cells and the tumour microenvironment (TME) in the liver. However, the molecular… read more here.
Keywords: mir 181a; crc; colorectal cancer; liver metastasis ... See more keywords
Neuroendocrine liver metastasis: The chance to be cured after liver surgery
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DOI: 10.1002/jso.24563
Abstract: Neuroendocrine liver metastasis tumors (NELM) are a heterogeneous group of neoplasms with varied histologic features and a wide range of clinical behaviors. We aimed to identify the fraction of patients cured after liver surgery for… read more here.
Keywords: neuroendocrine liver; liver metastasis; cured liver; liver surgery ... See more keywords
Neutrophil: Lymphocyte ratio as a method of predicting complications following hepatic resection for colorectal liver metastasis
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DOI: 10.1002/jso.24996
Abstract: Approximately 30‐50% of patients with colorectal cancer develop liver metastasis for which liver resection is the only hope for potential cure. However, hepatic resection is associated with considerable morbidity. The aim was to detect early… read more here.
Keywords: hepatic resection; neutrophil lymphocyte; lymphocyte ratio; liver metastasis ... See more keywords
Residual tumor volume discriminates prognosis after surgery for neuroendocrine liver metastasis
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DOI: 10.1002/jso.25811
Abstract: We developed objective measurements of preoperative and residual tumor volume, and debulking rate, to evaluate their prognostic value for neuroendocrine liver metastasis (NELM). read more here.
Keywords: tumor volume; liver metastasis; residual tumor; neuroendocrine liver ... See more keywords
Liver metastasis in soft tissue sarcoma at initial presentation
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DOI: 10.1002/jso.27007
Abstract: Noncontrast computed tomography of the chest is the standard imaging modality for cancer staging in patients with soft tissue sarcoma (STS), but appropriate candidates for liver screening have not been clarified. read more here.
Keywords: soft tissue; tissue sarcoma; metastasis soft; liver metastasis ... See more keywords
Neoadjuvant chemotherapy does not increase risk for anastomotic leak for simultaneous resection of primary colon cancer with synchronous liver metastasis: A NSQIP-colectomy analysis.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of surgical oncology"
DOI: 10.1002/jso.27242
Abstract: BACKGROUND AND OBJECTIVES In patients with colon cancer with synchronous liver metastasis, treatment algorithms are complex and often require multidisciplinary evaluation. Neoadjuvant therapy is frequently utilized, but there is an unclear relationship with postoperative outcomes… read more here.
Keywords: synchronous liver; colon cancer; neoadjuvant chemotherapy; liver metastasis ... See more keywords