In Silico Prediction of Human and Rat Liver Microsomal Stability via Machine Learning Methods.
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DOI: 10.1021/acs.chemrestox.2c00207
Abstract: Liver microsomal stability is an important property considered for the screening of drug candidates in the early stage of drug development. Determination of hepatic metabolic stability can be performed by an in vitro assay, but… read more here.
Keywords: machine learning; learning methods; stability; microsomal stability ... See more keywords
Perspective of the Induction of Liver Microsomal Cytochrome P450s by Chemical Compounds
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DOI: 10.1124/dmd.122.000891
Abstract: The concept of hepatic induction of drug-metabolizing cytochrome P450s (P450s) by xenobiotics, including therapeutic drugs, was proposed in the early 1960s. A polycyclic aromatic hydrocarbon and phenobarbital have been the two major inducers used to… read more here.
Keywords: cytochrome p450s; induction liver; p450s; perspective induction ... See more keywords
Pharmacokinetics and in vitro liver microsomal enzyme metabolism of Xylopic acid.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.2139/ssrn.4249776
Abstract: Xylopic acid (XA) is a bioactive diterpene kaurene isolate of the Guinea pepper fruit, Xylopia aethiopica (Annonaceae) with numerous well-established biological effects. In this study, we aimed to fill certain scientific voids in terms of… read more here.
Keywords: xylopic acid; enzyme metabolism; vitro liver; microsomal enzyme ... See more keywords