Interspecies metabolic diversity of harmaline and harmine in in vitro 11 mammalian liver microsomes.
Sign Up to like & getrecommendations! Published in 2017 at "Drug testing and analysis"
DOI: 10.1002/dta.2028
Abstract: The β-carboline alkaloids harmaline and harmine are widely present in hallucinogenic plants with great potential for treating depression, Parkinson's disease, and Alzheimer's disease. The present study was to elucidate metabolic difference of harmaline and harmine… read more here.
Keywords: mammalian liver; harmaline harmine; liver microsomes; harmine ... See more keywords
The metabolism of valerylfentanyl using human liver microsomes and zebrafish larvae.
Sign Up to like & getrecommendations! Published in 2022 at "Drug testing and analysis"
DOI: 10.1002/dta.3233
Abstract: Valerylfentanyl-a novel synthetic opioid, less potent than fentanyl, has been reported in biological samples, but there are limited studies on its pharmacokinetic properties. The goal of this study was to elucidate the metabolism of valerylfentanyl… read more here.
Keywords: liver; valerylfentanyl using; liver microsomes; valerylfentanyl ... See more keywords
Hepatic microsomal metabolism of BDE-47 and BDE-99 by lesser snow geese and Japanese quail.
Sign Up to like & getrecommendations! Published in 2017 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2017.05.027
Abstract: In the present study, we investigated the oxidative biotransformation of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) and 2,2',4,4',5-pentabromodiphenyl ether (BDE-99) by liver microsomes from wild lesser snow geese (Chen caerulescens caerulescens) and domesticated Japanese quail (Coturnix japonica). Formation… read more here.
Keywords: bde; ether bde; japanese quail; lesser snow ... See more keywords
Biotransformation of NSAIDs by pig liver microsomes in vitro: Kinetics, metabolites identification and toxicity prediction.
Sign Up to like & getrecommendations! Published in 2017 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2017.08.026
Abstract: Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most frequently used pharmaceuticals in animals. In the current study, the biotransformation of five NSAIDs by pig liver microsomes (PLMs) was studied. The pseudo-first-order kinetics mode was… read more here.
Keywords: pig liver; nsaids pig; toxicity; biotransformation nsaids ... See more keywords
In vitro enantioselective study of the toxicokinetic effects of chiral fungicide tebuconazole in human liver microsomes.
Sign Up to like & getrecommendations! Published in 2019 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2019.05.071
Abstract: Tebuconazole (TEB) is a chiral triazole fungicide that is globally marketed and used as a racemic mixture to control plant pathogens. Due to its use as a racemic mixture, TEB may exhibit enantioselective toxicokinetics toward… read more here.
Keywords: teb; metabolism; liver; vitro enantioselective ... See more keywords
Stereostructure-activity mechanism of cyproconazole by cytochrome P450 in rat liver microsomes: A combined experimental and computational study.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of hazardous materials"
DOI: 10.1016/j.jhazmat.2021.125764
Abstract: Cyproconazole (CPZ), representing the chiral triazole fungicides, is widely used in the pharmaceutical and agricultural fields. To clarify its potential adverse effects on the generalized CYP-mediated processes within mammalian, a comparative experimental and computational approach… read more here.
Keywords: metabolism; rat liver; experimental computational; cpz ... See more keywords
In vitro metabolism of 4, 5‐dimethoxycanthin‐6‐one by human liver microsomes and its inhibition on human CYP1A2
Sign Up to like & getrecommendations! Published in 2017 at "Life Sciences"
DOI: 10.1016/j.lfs.2017.09.031
Abstract: Aims: P. quassioides is a traditional Chinese medicine used for the treatment of gastroenteritis, snakebite, infection and hypertension in China. 4, 5‐dimethoxycanthin‐6‐one is one of the main active canthinone alkaloid isolated from P. quassioides. The… read more here.
Keywords: medicine; dimethoxycanthin one; metabolism dimethoxycanthin; liver microsomes ... See more keywords
Stereochemistry of chiral pesticide uniconazole and enantioselective metabolism in rat liver microsomes
Sign Up to like & getrecommendations! Published in 2021 at "Pesticide Biochemistry and Physiology"
DOI: 10.1016/j.pestbp.2021.104964
Abstract: Abstract In this work, stereochemistry of uniconazole enantiomers and their metabolism behaviors in rat liver microsomes have been researched. Significance analysis has been applied in data processing. Absolute configurations of uniconazole enantiomers were identified through… read more here.
Keywords: uniconazole enantiomers; metabolism; pesticide; rat liver ... See more keywords
Probing the Role of CYP2 Enzymes in the Atropselective Metabolism of Polychlorinated Biphenyls Using Liver Microsomes from Transgenic Mouse Models
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Research in Toxicology"
DOI: 10.1021/acs.chemrestox.2c00276
Abstract: Chiral polychlorinated biphenyls (PCB) are environmentally relevant developmental neurotoxicants. Because their hydroxylated metabolites (OH-PCBs) are also neurotoxic, it is necessary to determine how PCB metabolism affects the developing brain, for example, in mouse models. Because… read more here.
Keywords: metabolism; polychlorinated biphenyls; using liver; pcb ... See more keywords
Enantioselective Metabolic Mechanism and Metabolism Pathway of Pydiflumetofen in Rat Liver Microsomes: In Vitro and In Silico Study.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c06928
Abstract: Pydiflumetofen (PYD) has been used worldwide. However, the enantioselective fate of PYD within mammals is not clear. Thus, the enantioselective metabolism and its potential mechanisms of PYD were explored via in vitro and in silico.… read more here.
Keywords: metabolism; liver microsomes; rat liver; vitro silico ... See more keywords
Lead Diversification at the Nanomole Scale Using Liver Microsomes and Quantitative Nuclear Magnetic Resonance Spectroscopy: Application to Phosphodiesterase 2 Inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b00116
Abstract: In this report, we describe a method whereby lead molecules can be converted into several new analogues each using liver microsomes. Less than one micromole of substrate is incubated with liver microsomes (mouse, rat, hamster,… read more here.
Keywords: lead diversification; phosphodiesterase; using liver; spectroscopy ... See more keywords