TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk.
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32802
Abstract: BACKGROUND AND AIMS Major genomic drivers of hepatocellular carcinoma (HCC) are nowadays well recognized, although models to establish their roles in human HCC initiation remain scarce. Here, we used human liver organoids in experimental systems to… read more here.
Keywords: r249s mutation; hcc; liver organoids; tp53 ... See more keywords
Gene Regulatory Network Analysis and Engineering Directs Development and Vascularization of Multilineage Human Liver Organoids
Sign Up to like & getrecommendations! Published in 2020 at "Cell systems"
DOI: 10.1016/j.cels.2020.11.002
Abstract: SUMMARY Pluripotent stem cell (PSC)-derived organoids have emerged as novel multicellular models of human tissue development but display immature phenotypes, aberrant tissue fates, and a limited subset of cells. Here, we demonstrate that integrated analysis… read more here.
Keywords: liver organoids; cell; development; analysis engineering ... See more keywords
Flow enhances phenotypic and maturation of adult rat liver organoids.
Sign Up to like & getrecommendations! Published in 2020 at "Biofabrication"
DOI: 10.1088/1758-5090/abb538
Abstract: A biologically relevant in vitro model of hepatic microtissue would be a valuable tool for the preclinical study of pharmacokinetics and metabolism. Although considerable advances have been made in recent years in the establishment of… read more here.
Keywords: liver organoids; enhances phenotypic; liver; flow enhances ... See more keywords
Development of a high-throughput micropatterned agarose scaffold for consistent and reproducible hPSC-derived liver organoids
Sign Up to like & getrecommendations! Published in 2022 at "Biofabrication"
DOI: 10.1088/1758-5090/ac933c
Abstract: Liver organoids represent emerging human-relevant in vitro liver models that have a wide range of biomedical applications in basic medical studies and preclinical drug discovery. However, the generation of liver organoids currently relies on the… read more here.
Keywords: liver; micropatterned agarose; agarose scaffold; liver organoids ... See more keywords
Progress in human liver organoids
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjaa013
Abstract: Abstract Understanding the development, regeneration, and disorders of the liver is the major goal in liver biology. Current mechanistic knowledge of human livers has been largely derived from mouse models and cell lines, which fall… read more here.
Keywords: progress human; liver organoids; biology; human liver ... See more keywords
Self-Assembled Matrigel-Free iPSC-Derived Liver Organoids Demonstrate Wide-Ranging Highly Differentiated Liver Functions
Sign Up to like & getrecommendations! Published in 2022 at "Stem Cells"
DOI: 10.1093/stmcls/sxac090
Abstract: Abstract Human induced pluripotent stem cell (iPSC)-derived liver organoids serve as models of organogenesis, disease, drug screening, and regenerative medicine. Prevailing methods for generating organoids rely on Matrigel, whose batch-to-batch variability and xenogeneic source pose… read more here.
Keywords: ipsc derived; liver; derived liver; liver organoids ... See more keywords
Human liver organoids: From generation to applications.
Sign Up to like & getrecommendations! Published in 2023 at "Hepatology"
DOI: 10.1097/hep.0000000000000343
Abstract: In the last decade, research into human hepatology has been revolutionized by the development of mini human livers in a dish. These liver organoids are formed by self-organizing stem cells and resemble their native counterparts… read more here.
Keywords: generation applications; development; organoids generation; liver organoids ... See more keywords
Modelling T-cell immunity against hepatitis C virus with liver organoids in a microfluidic coculture system
Sign Up to like & getrecommendations! Published in 2022 at "Open Biology"
DOI: 10.1098/rsob.210320
Abstract: Hepatitis C virus (HCV) remains a global public health challenge with an estimated 71 million people chronically infected, with surges in new cases and no effective vaccine. New methods are needed to study the human… read more here.
Keywords: coculture system; hepatitis virus; liver organoids; cell ... See more keywords
In vitro construction of liver organoids with biomimetic lobule structure by a multicellular 3D bioprinting strategy
Sign Up to like & getrecommendations! Published in 2023 at "Cell Proliferation"
DOI: 10.1111/cpr.13465
Abstract: Liver disease is one of the serious threats to human life and health. Three‐dimensional (3D) liver models, which simulate the structure and function of natural liver tissue in vitro, have become a common demand in… read more here.
Keywords: liver; lobule; structure; organoids biomimetic ... See more keywords
Investigation of Clinical Safety of Human iPS Cell-Derived Liver Organoid Transplantation to Infantile Patients in Porcine Model
Sign Up to like & getrecommendations! Published in 2020 at "Cell Transplantation"
DOI: 10.1177/0963689720964384
Abstract: Transplantation of liver organoids has been investigated as a treatment alternative to liver transplantation for chronic liver disease. Transportal approach can be considered as a method of delivering organoids to the liver. It is important… read more here.
Keywords: derived liver; liver organoids; transplantation; translocation ... See more keywords
Liver organoids in domestic animals: an expected promise for metabolic studies
Sign Up to like & getrecommendations! Published in 2021 at "Veterinary Research"
DOI: 10.1186/s13567-021-00916-y
Abstract: The liver is one of the most important organs, both in terms of the different metabolic processes (energy, lipid, ferric, uric, etc.) and of its central role in the processes of detoxification of substances of… read more here.
Keywords: liver organoids; promise metabolic; domestic animals; animals expected ... See more keywords