Antisense oligonucleotide silencing of a glycosyltransferase, Poglut1, improves the liver phenotypes in mouse models of Alagille syndrome.
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DOI: 10.1097/hep.0000000000000380
Abstract: BACKGROUND AND AIMS Paucity of intrahepatic bile ducts is caused by various etiologies and often leads to cholestatic liver disease. For example, in patients with Alagille syndrome (ALGS), which is a genetic disease primarily caused… read more here.
Keywords: antisense oligonucleotide; jag1; alagille syndrome; liver phenotypes ... See more keywords
Liver phenotypes in PCOS: Analysis of exogenous and inherited risk factors for liver injury in two European cohorts
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DOI: 10.1111/liv.15527
Abstract: Fatty liver disease (FLD) is common in women with polycystic ovary syndrome (PCOS). Here, we use non‐invasive tests to quantify liver injury in women with PCOS and analyse whether FLD‐associated genetic variants contribute to liver… read more here.
Keywords: liver injury; liver phenotypes; pcos analysis; analysis exogenous ... See more keywords