Activation of the Liver X Receptor Pathway Inhibits HBV Replication in Primary Human Hepatocytes
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology"
DOI: 10.1002/hep.31217
Abstract: Hepatitis B virus (HBV) infection is ranked among the top health priorities worldwide. Accumulating evidence suggests that HBV infection and replication are closely associated with liver metabolism. The liver X receptors (LXRs), which belong to… read more here.
Keywords: liver receptor; receptor pathway; hbv infection; pathway inhibits ... See more keywords
Promoting intestinal lymphatic transport targets a liver‐X receptor (LXR) agonist (WAY‐252,623) to lymphocytes and enhances immunomodulation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2019.01.002
Abstract: ABSTRACT Lymphocytes play a central role in the pathology of a range of chronic conditions such as autoimmune disease, transplant rejection, leukemia, lymphoma HIV/AIDs and cardiometabolic diseases such as atherosclerosis. Current treatments for lymphocyte‐associated conditions… read more here.
Keywords: way 252; liver receptor; lymphatic transport; 252 623 ... See more keywords
Ursolic Acid, a Novel Liver X Receptor α (LXRα) Antagonist Inhibiting Ligand-Induced Nonalcoholic Fatty Liver and Drug-Induced Lipogenesis.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.8b04116
Abstract: Nonalcoholic fatty liver disease (NAFLD) is a very common liver disease, and its incidence has significantly increased worldwide. The liver X receptor α (LXRα) is a multifunctional nuclear receptor that controls lipid homeostasis. Inhibition of… read more here.
Keywords: receptor lxr; nonalcoholic fatty; fatty liver; liver receptor ... See more keywords
Diketopiperazine-Type Alkaloids from a Deep-Sea-Derived Aspergillus puniceus Fungus and Their Effects on Liver X Receptor α.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.9b00055
Abstract: Eight new diketopiperazine-type alkaloids including four oxepin-containing diketopiperazine-type alkaloids, oxepinamides H-K (1-4), and four 4-quinazolinone alkaloids, puniceloids A-D (5-8), together with two known analogues (9 and 10), were isolated from the culture broth extracts of… read more here.
Keywords: type alkaloids; deep sea; aspergillus puniceus; sea derived ... See more keywords
Liver X Receptor exerts a protective effect against the oxidative stress in the peripheral nerve
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-20980-3
Abstract: Reactive oxygen species (ROS) modify proteins and lipids leading to deleterious outcomes. Thus, maintaining their homeostatic levels is vital. This study highlights the endogenous role of LXRs (LXRα and β) in the regulation of oxidative… read more here.
Keywords: receptor exerts; liver receptor; stress peripheral; stress ... See more keywords
Regulation of liver receptor homologue-1 by DDB2 E3 ligase activity is critical for hepatic glucose metabolism
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-41411-x
Abstract: Liver receptor homologue-1 (LRH-1) plays a critical role in hepatic metabolism and disease. Here we show that LRH-1 protein stability is regulated by the cullin 4 (CUL4) E3 ubiquitin ligase complex. We found that DNA… read more here.
Keywords: receptor homologue; metabolism; liver receptor; glucose metabolism ... See more keywords
Liver X receptor controls follicular helper T cell differentiation via repression of TCF-1
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2213793120
Abstract: Significance Tfh cells are indispensable for effective humoral immunity against infection but detrimental in autoimmune diseases. We demonstrate that LXR, an oxysterol sensor previously known to integrate metabolic and inflammatory signaling, acts as a critical… read more here.
Keywords: tfh cell; cell differentiation; cell; liver receptor ... See more keywords
Liver X receptor: a potential target in the treatment of atherosclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2022.2117610
Abstract: ABSTRACT Introduction Liver X receptors (LXRs) are master regulators of atherogenesis. Their anti-atherogenic potential has been attributed to their role in the inhibition of macrophage-mediated inflammation and promotion of reverse cholesterol transport. Owing to the… read more here.
Keywords: atherosclerosis liver; liver receptor; lxr; lxr agonists ... See more keywords
Inhibition of protein arginine methyltransferase 3 activity selectively impairs liver X receptor‐driven transcription of hepatic lipogenic genes in vivo
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14361
Abstract: Agonists for the liver X receptor (LXR) are considered promising therapeutic moieties in cholesterol‐driven diseases by promoting cellular cholesterol efflux pathways. However, current clinical application of these agents is hampered by concomitant LXR‐induced activation of… read more here.
Keywords: protein arginine; liver receptor; lxr; arginine methyltransferase ... See more keywords
Liver X receptor activation inhibits SGLT2‐mediated glucose transport in human renal proximal tubular cells
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Physiology"
DOI: 10.1113/ep086478
Abstract: What is the central question of this study? The liver X receptor (LXR) has been reported to regulate several membrane transporters. It is imperative to investigate whether LXR activation regulates SGLT2‐mediated glucose transport in human… read more here.
Keywords: sglt2 mediated; liver receptor; glucose transport; transport human ... See more keywords
Inhibition of Chikungunya Virus Replication in Primary Human Fibroblasts by Liver X Receptor Agonist
Sign Up to like & getrecommendations! Published in 2019 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01220-19
Abstract: The mosquito-borne chikungunya virus (CHIKV) causes acute pain and joint inflammation, and in recent years the virus has caused large epidemics in previously CHIKV-free geographic areas. ABSTRACT The mosquito-borne chikungunya virus (CHIKV) causes acute pain… read more here.
Keywords: liver receptor; inhibition chikungunya; replication; chikungunya virus ... See more keywords