Notch‐triggered maladaptation of liver sinusoidal endothelium aggravates nonalcoholic steatohepatitis through endothelial nitric oxide synthase
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32332
Abstract: Although NASH can lead to severe clinical consequences, including cirrhosis and hepatocellular carcinoma, no effective treatment is currently available for this disease. Increasing evidence indicates that LSECs play a critical role in NASH pathogenesis; however,… read more here.
Keywords: sinusoidal endothelium; liver sinusoidal; maladaptation liver; notch triggered ... See more keywords
Raman spectroscopy-based insight into lipid droplets presence and contents in liver sinusoidal endothelial cells and hepatocytes.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of biophotonics"
DOI: 10.1002/jbio.201800290
Abstract: Liver sinusoidal endothelial cells (LSECs), a type of endothelial cells with unique morphology and function, play an important role in the liver hemostasis, and LSECs dysfunction is involved in the development of nonalcoholic fatty liver… read more here.
Keywords: sinusoidal endothelial; presence; liver sinusoidal; lipid droplets ... See more keywords
Sensitivity of Kupffer cells and liver sinusoidal endothelial cells to ricin toxin and ricin toxin–Ab complexes
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.4a0419-123r
Abstract: Ricin toxin is a plant‐derived, ribosome‐inactivating protein that is rapidly cleared from circulation by Kupffer cells (KCs) and liver sinusoidal endothelial cells (LSECs)—with fatal consequences. Rather than being inactivated, ricin evades normal degradative pathways and… read more here.
Keywords: ricin; ricin toxin; kupffer cells; liver sinusoidal ... See more keywords
Advanced Method for Isolation of Mouse Hepatocytes, Liver Sinusoidal Endothelial Cells, and Kupffer Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6700-1_21
Abstract: Separation of pure cell populations from the liver is a prerequisite to study the role of hepatic parenchymal and non-parenchymal cells in liver physiology, pathophysiology, and immunology. Traditional methods for hepatic cell separation usually purify… read more here.
Keywords: sinusoidal endothelial; kupffer cells; liver sinusoidal; endothelial cells ... See more keywords
Generation of proliferating human liver sinusoidal endothelial cells (upcyte® LSECS)
Sign Up to like & getrecommendations! Published in 2017 at "Drug Metabolism and Pharmacokinetics"
DOI: 10.1016/j.dmpk.2016.10.204
Abstract: CONCLUSION In conclusion, we developed a technique which causes primary human LSECs and hepatocytes to proliferate up to 40 population doublings whilst still retaining an adult phenotype when cultured at confluence. upcyte® LSECs retained important… read more here.
Keywords: sinusoidal endothelial; upcyte lsecs; liver sinusoidal; endothelial cells ... See more keywords
Single-Cell Transcriptomics Reveals Zone-Specific Alterations of Liver Sinusoidal Endothelial Cells in Cirrhosis
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2020.12.007
Abstract: Background Dysfunction of liver sinusoidal endothelial cells (LSECs) is permissive for the progression of liver fibrosis and cirrhosis and responsible for its clinical complications. Here, we have mapped the spatial distribution of heterogeneous liver ECs… read more here.
Keywords: cirrhotic mice; liver sinusoidal; cirrhosis; sinusoidal endothelial ... See more keywords
Quantification of fenestrations in liver sinusoidal endothelial cells by atomic force microscopy.
Sign Up to like & getrecommendations! Published in 2017 at "Micron"
DOI: 10.1016/j.micron.2017.06.005
Abstract: Liver sinusoidal endothelial cells present unique morphology characterized by the presence of transmembrane pores called fenestrations. The size and number of fenestrations in live cells change dynamically in response to variety of chemical and physical… read more here.
Keywords: sinusoidal endothelial; microscopy; force microscopy; liver sinusoidal ... See more keywords
Restoration of liver sinusoidal cell phenotypes by statins improves portal hypertension and histology in rats with NASH
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-56366-2
Abstract: Non-alcoholic steatohepatitis (NASH) is a common chronic liver disorder in developed countries, with the associated clinical complications driven by portal hypertension (PH). PH may precede fibrosis development, probably due to endothelial dysfunction at early stages… read more here.
Keywords: liver; liver sinusoidal; portal hypertension; cell ... See more keywords
Liver Sinusoidal Endothelial Cell: An Update.
Sign Up to like & getrecommendations! Published in 2017 at "Seminars in liver disease"
DOI: 10.1055/s-0037-1617455
Abstract: This update focuses on two main topics. First, recent developments in our understanding of liver sinusoidal endothelial cell (LSEC) function will be reviewed, specifically elimination of blood-borne waste, immunological function of LSECs, interaction of LSECs… read more here.
Keywords: cell update; sinusoidal endothelial; endothelial cell; liver ... See more keywords
Liver sinusoidal endothelial cells as iron sensors.
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood-2016-12-754499
Abstract: The continuous turnover of erythrocyte iron requires intercommunication between multiple cell types for homeostasis, including cells participating in iron uptake (enterocytes), utilization (erythroid precursors), recycling (reticuloendothelial macrophages), and storage (hepatocytes). Coordination of iron flux between… read more here.
Keywords: sinusoidal endothelial; iron sensors; liver sinusoidal; cells iron ... See more keywords
Liver sinusoidal endothelial cells induce BMP6 expression in response to non-transferrin bound iron.
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2022016987
Abstract: Homeostatic adaptation to systemic iron overload involves transcriptional induction of bone morphogenetic protein 6 (BMP6) in liver sinusoidal endothelial cells (LSECs). BMP6 is then secreted to activate signaling to the iron hormone hepcidin (HAMP) in… read more here.
Keywords: liver sinusoidal; sinusoidal endothelial; transferrin; bmp6 ... See more keywords