Co-culture system of hepatocytes and endothelial cells: two in vitro approaches for enhancing liver-specific functions of hepatocytes
Sign Up to like & getrecommendations! Published in 2018 at "Cytotechnology"
DOI: 10.1007/s10616-018-0219-3
Abstract: Although hepatocyte transplantation and bioartificial liver support system provide new promising opportunities for those patients waiting for liver transplantation, hepatocytes are easily losing liver-specific functions by using the common in vitro cultured methods. The co-culture… read more here.
Keywords: system; specific functions; liver specific; culture ... See more keywords
A serum-free medium suitable for maintaining cell morphology and liver-specific function in induced human hepatocytes
Sign Up to like & getrecommendations! Published in 2018 at "Cytotechnology"
DOI: 10.1007/s10616-018-0289-2
Abstract: AbstracthiHep is a new type of hepatocyte-like cell that is predicted to be a potential unlimited source of hepatocytes for a bioartificial liver. However, hiHep cannot currently be used in clinical settings because serum must… read more here.
Keywords: liver specific; medium; free medium; serum free ... See more keywords
Controlled cell morphology and liver-specific function of engineered primary hepatocytes by fibroblast layer cell densities.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of bioscience and bioengineering"
DOI: 10.1016/j.jbiosc.2018.02.006
Abstract: Engineered primary hepatocytes, including co-cultured hepatocyte sheets, are an attractive to basic scientific and clinical researchers because they maintain liver-specific functions, have reconstructed cell polarity, and have high transplantation efficiency. However, co-culture conditions regarding engineered… read more here.
Keywords: primary hepatocytes; tig 118; liver specific; morphology liver ... See more keywords
Liver-specific metabolomics characterizes the hepatotoxicity of Dioscorea bulbifera rhizome in rats by integration of GC-MS and 1H-NMR.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2018.08.014
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Dioscorea bulbifera rhizome (DBR), one type of herbal medicine, is extensively used in both Indian and Chinese system of traditional medicine. It has been effective in treating various diseases, such as sore throat,… read more here.
Keywords: medicine; dioscorea bulbifera; bulbifera rhizome; liver specific ... See more keywords
Liver-specific deletion of Mttp versus Tm6sf2 reveals distinct defects in stepwise VLDL assembly
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Lipid Research"
DOI: 10.1016/j.jlr.2021.100080
Abstract: HE AUTHORS. Pub an open access articl Elizabeth P. Newberry, Gregory W. Strout, James A. J. Fitzpatrick, and Nicholas O. Davidson* Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA; Washington University… read more here.
Keywords: medicine; louis usa; washington university; liver specific ... See more keywords
Defining the functionally sufficient regulatory region and liver-specific roles of the erythropoietin gene by transgene complementation.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119075
Abstract: BACKGROUND Erythropoietin (EPO) is an essential growth factor for erythroid cells and is mainly secreted from the kidneys and subsidiarily from the livers of adult mammals in an anemia/hypoxia-inducible manner. AIM AND METHOD To elucidate… read more here.
Keywords: liver specific; epo gene; transgene complementation; gene ... See more keywords
Prevent and Reverse Metabolic Dysfunction-Associated Steatohepatitis and Hepatic Fibrosis via mRNA-Mediated Liver-Specific Antibody Therapy.
Sign Up to like & getrecommendations! Published in 2024 at "ACS nano"
DOI: 10.1021/acsnano.4c13404
Abstract: Chronic exposure of the liver to multiple insults culminates in the development of metabolic dysfunction-associated steatohepatitis (MASH), a complicated metabolic syndrome characterized by hepatic steatosis and inflammation, typically accompanied by progressive fibrosis. Despite extensive clinical… read more here.
Keywords: mrna mediated; fibrosis; antibody; specific antibody ... See more keywords
Harmonizing heterogeneous transcriptomics datasets for machine learning-based analysis to identify spaceflown murine liver-specific changes
Sign Up to like & getrecommendations! Published in 2024 at "NPJ Microgravity"
DOI: 10.1038/s41526-024-00379-3
Abstract: NASA has employed high-throughput molecular assays to identify sub-cellular changes impacting human physiology during spaceflight. Machine learning (ML) methods hold the promise to improve our ability to identify important signals within highly dimensional molecular data.… read more here.
Keywords: transcriptomics datasets; analysis; machine learning; based analysis ... See more keywords
Characterization of Focal Liver Lesions using CEUS and MRI with Liver-Specific Contrast Media: Experience of a Single Radiologic Center.
Sign Up to like & getrecommendations! Published in 2017 at "Ultraschall in der Medizin"
DOI: 10.1055/s-0043-105264
Abstract: AIM The purpose of this study was to compare contrast-enhanced ultrasound (CEUS), magnetic resonance imaging (MRI) using liver-specific contrast agent and a combination of both for the characterization of focal liver lesions (FLL). METHODS 83… read more here.
Keywords: ceus mri; liver specific; contrast; liver ... See more keywords
Circulating liver-specific microRNAs as noninvasive diagnostic biomarkers of hepatic diseases in human
Sign Up to like & getrecommendations! Published in 2019 at "Biomarkers"
DOI: 10.1080/1354750x.2018.1528631
Abstract: Abstract Context: Hepatitis is an endemic disease worldwide leading to chronic and debilitating cancers. The viral agents and hepatotoxic substances lead to damage of hepatocytes and release of damage associated molecules in circulation. The lack… read more here.
Keywords: specific micrornas; liver specific; mir; hepatic diseases ... See more keywords
Induction of liver-specific intrahepatic myeloid cells aggregation expands CD8 T cell and inhibits growth of murine hepatoma
Sign Up to like & getrecommendations! Published in 2018 at "OncoImmunology"
DOI: 10.1080/2162402x.2018.1502129
Abstract: ABSTRACT Toll-Like Receptor 9 (TLR9) stimulation selectively triggers the formation of a cell cluster termed intrahepatic myeloid aggregation for T cell expansion” (iMATE) in a mouse chronic viral hepatitis model. iMATE expands cytotoxic T cells… read more here.
Keywords: cell; liver specific; model; myeloid ... See more keywords