Nondestructive Optical Toxicity Assays of 3D Liver Spheroids with Optical Coherence Tomography
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Biosystems"
DOI: 10.1002/adbi.201700212
Abstract: Drug‐induced liver injury (DILI) is the leading cause of failure in preclinical drug development and withdrawals. Given the central role of the liver in drug metabolism and detoxification, strong incentives exist to create new physiologically… read more here.
Keywords: coherence tomography; optical coherence; dili; liver spheroids ... See more keywords
Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-14815-w
Abstract: Human in vitro physiological models studying disease and drug treatment effects are urgently needed as more relevant tools to identify new drug targets and therapies. We have developed a human microfluidic two-organ-chip model to study… read more here.
Keywords: functional coupling; islet; liver spheroids; human pancreatic ... See more keywords
Controlled fabrication of functional liver spheroids with microfluidic flow cytometric printing
Sign Up to like & getrecommendations! Published in 2022 at "Biofabrication"
DOI: 10.1088/1758-5090/ac8622
Abstract: Multicellular liver spheroids are 3D culture models useful in the development of therapies for liver fibrosis. While these models can recapitulate fibrotic disease, current methods for generating them via random aggregation are uncontrolled, yielding spheroids… read more here.
Keywords: flow cytometric; liver; microfluidic flow; spheroids microfluidic ... See more keywords