Quantitative Proteomic Analysis of Simian Primary Hepatocytes Reveals Candidate Molecular Markers for Permissiveness to Relapsing Malaria Plasmodium cynomolgi
Sign Up to like & getrecommendations! Published in 2019 at "PROTEOMICS"
DOI: 10.1002/pmic.201900021
Abstract: A major obstacle impeding malaria research is the lack of an in vitro system capable of supporting infection through the entire liver stage cycle of the parasite, including that of the dormant forms known as… read more here.
Keywords: quantitative proteomic; primary hepatocytes; infection; liver stage ... See more keywords
Discovery of Druggable Host Factors Critical to Plasmodium Liver-Stage Infection.
Sign Up to like & getrecommendations! Published in 2019 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2019.05.011
Abstract: Plasmodium parasites undergo an obligatory and asymptomatic developmental stage within the liver before infecting red blood cells to cause malaria. The hijacked host pathways critical to parasite infection during this hepatic phase remain poorly understood.… read more here.
Keywords: host factors; infection; liver stage; host ... See more keywords
Transcriptome and histone epigenome of Plasmodium vivax salivary-gland sporozoites point to tight regulatory control and mechanisms for liver-stage differentiation in relapsing malaria.
Sign Up to like & getrecommendations! Published in 2019 at "International journal for parasitology"
DOI: 10.1016/j.ijpara.2019.02.007
Abstract: Plasmodium vivax is the key obstacle to malaria elimination in Asia and Latin America, largely attributed to its ability to form resilient hypnozoites (sleeper cells) in the host liver that escape treatment and cause relapsing… read more here.
Keywords: vivax; plasmodium vivax; liver stage; liver ... See more keywords
STK35L1 regulates host cell cycle-related genes and is essential for Plasmodium infection during the liver stage of malaria.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2021.112764
Abstract: Protein kinases of both the parasite and the host are crucial in parasite invasion and survival and might act as drug targets against drug-resistant malaria. STK35L1 was among the top five hits in kinome-wide screening,… read more here.
Keywords: stk35l1; liver stage; malaria; host ... See more keywords
Developing Plasmodium vivax Resources for Liver Stage Study in the Peruvian Amazon Region.
Sign Up to like & getrecommendations! Published in 2018 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.7b00198
Abstract: To develop new drugs and vaccines for malaria elimination, it will be necessary to discover biological interventions, including small molecules that act against Plasmodium vivax exoerythrocytic forms. However, a robust in vitro culture system for… read more here.
Keywords: amazon region; vivax sporozoites; vivax; plasmodium vivax ... See more keywords
Metabolic, Pharmacokinetic, and Activity Profile of the Liver Stage Antimalarial (RC-12)
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c01099
Abstract: The catechol derivative RC-12 (WR 27653) (1) is one of the few non-8-aminoquinolines with good activity against hypnozoites in the gold-standard Plasmodium cynomolgi–rhesus monkey (Macaca mulatta) model, but in a small clinical trial, it had… read more here.
Keywords: liver; profile; liver stage; activity ... See more keywords
Host cell cytosolic immune response during Plasmodium liver stage development
Sign Up to like & getrecommendations! Published in 2018 at "FEMS Microbiology Reviews"
DOI: 10.1093/femsre/fuy007
Abstract: Abstract Recent years have witnessed a great gain in knowledge regarding parasite–host cell interactions during Plasmodium liver stage development. It is now an accepted fact that a large percentage of sporozoites invading hepatocytes fail to… read more here.
Keywords: host cell; plasmodium liver; liver stage; host ... See more keywords
Identification of Hsp90 Inhibitors with Anti-Plasmodium Activity
Sign Up to like & getrecommendations! Published in 2018 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01799-17
Abstract: ABSTRACT Malaria remains a global health burden partly due to Plasmodium parasite resistance to first-line therapeutics. The molecular chaperone heat shock protein 90 (Hsp90) has emerged as an essential protein for blood-stage Plasmodium parasites, but… read more here.
Keywords: hsp90; hsp90 inhibitors; liver stage; blood stage ... See more keywords
Preparation of Decoquinate Solid Dispersion by Hot-Melt Extrusion as an Oral Dosage Form Targeting Liver-Stage Plasmodium Infection
Sign Up to like & getrecommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.02218-21
Abstract: Liver-stage Plasmodium in humans is an early stage of malarial infection. Decoquinate (DQ) has a potent multistage antimalarial activity. ABSTRACT Liver-stage Plasmodium in humans is an early stage of malarial infection. Decoquinate (DQ) has a… read more here.
Keywords: plasmodium; stage plasmodium; liver stage; stage ... See more keywords
A Plasmodium Parasite with Complete Late Liver Stage Arrest Protects against Preerythrocytic and Erythrocytic Stage Infection in Mice
Sign Up to like & getrecommendations! Published in 2018 at "Infection and Immunity"
DOI: 10.1128/iai.00088-18
Abstract: ABSTRACT Genetically attenuated malaria parasites (GAP) that arrest during liver stage development are powerful immunogens and afford complete and durable protection against sporozoite infection. Late liver stage-arresting GAP provide superior protection against sporozoite challenge in… read more here.
Keywords: stage arresting; infection; late liver; liver stage ... See more keywords
Plasmodium berghei Purified Hemozoin Associated with DNA Strongly Inhibits P. berghei Liver-Stage Development in BALB/c Mice after Intravenous Inoculation
Sign Up to like & getrecommendations! Published in 2023 at "Infection and Immunity"
DOI: 10.1128/iai.00304-22
Abstract: In the acidic lysosome-like digestive vacuole, Plasmodium parasites crystallize heme from hemoglobin into hemozoin, or malaria pigment. Upon release of progeny merozoites, the residual hemozoin is phagocytized by macrophages principally in the liver and spleen… read more here.
Keywords: plasmodium; plasmodium berghei; hemozoin; liver stage ... See more keywords