Liver-targeted Nano-MitoPBN normalizes glucose metabolism by improving mitochondrial redox balance.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2019.119457
Abstract: Recent advances in Nanomedicine provide promising disease treatment through improved drug delivery efficiency, but clinical applications have encountered difficulties, largely due to the majority of injected nanoparticle is sequestered in liver. In contrast, liver cells… read more here.
Keywords: liver targeted; targeted nano; mitopbn normalizes; normalizes glucose ... See more keywords
Liver-targeted delivery of nucleic acid by liposomes modified with a glycoconjugate
Sign Up to like & getrecommendations! Published in 2017 at "Mendeleev Communications"
DOI: 10.1016/j.mencom.2017.11.030
Abstract: A drug delivery system based on liposomes has been modified by targeted vectors based on a glycoconjugate, and the vector structure has been optimized. The glycoconjugate in liposomes almost fourfold increases the transfection efficiency of… read more here.
Keywords: liver targeted; delivery; liposomes modified; targeted delivery ... See more keywords
Novel Liver-targeted conjugates of Glycogen Phosphorylase Inhibitor PSN-357 for the Treatment of Diabetes: Design, Synthesis, Pharmacokinetic and Pharmacological Evaluations
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep42251
Abstract: PSN-357, an effective glycogen phosphorylase (GP) inhibitor for the treatment for type 2 diabetics, is hampered in its clinical use by the poor selectivity between the GP isoforms in liver and in skeletal muscle. In… read more here.
Keywords: glycogen phosphorylase; phosphorylase inhibitor; liver targeted; psn 357 ... See more keywords
Systemic and Persistent Muscle Gene Expression in Rhesus Monkeys with a Liver De-Targeted Adeno-Associated Virus Vector.
Sign Up to like & getrecommendations! Published in 2017 at "Human gene therapy"
DOI: 10.1089/hum.2016.130
Abstract: The liver is a major off-target organ in gene therapy approaches for cardiac and musculoskeletal disorders. Intravenous administration of most of the naturally occurring adeno-associated virus (AAV) strains invariably results in vector genome sequestration within… read more here.
Keywords: vector; liver targeted; muscle; expression ... See more keywords
A3938 Renal angiotensin generation depends on hepatic angiotensinogen (AGT): evidence from a preclinical study with liver-targeted AGT small interfering RNA (siRNA)
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000548083.79380.91
Abstract: Objectives: AGT synthesis is believed to occur in liver, kidney, brain and adipocytes, so that selectively deleting hepatic AGT may not alter renal angiotensin (Ang) levels. Here we investigated whether arterial pressure lowering with liver-targeted… read more here.
Keywords: liver targeted; valsartan; targeted agt; agt ... See more keywords
A Novel Liver-targeted Testosterone Therapy for Sarcopenia in Androgen Deprived Men With Prostate Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvab116
Abstract: Abstract Objective Androgen deprivation therapy (ADT) reduces muscle and bone mass, increasing frailty in men with prostate cancer. The liver mediates the whole body anabolic effects of testosterone. Based on first-pass metabolism, liver-targeted testosterone treatment… read more here.
Keywords: liver targeted; prostate cancer; testosterone; targeted testosterone ... See more keywords
Liver-targeted liposomes for codelivery of curcumin and combretastatin A4 phosphate: preparation, characterization, and antitumor effects
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s188971
Abstract: Background Recent efforts have been focused on combining two or more therapeutic approaches with different mechanisms to enhance antitumor therapy. Moreover, nanosize drug-delivery systems for codelivering two drugs with proapoptotic and antiangiogenic activities have exhibited… read more here.
Keywords: antitumor; liver targeted; codelivery curcumin; cur ca4p ... See more keywords
High Prevalence of Insulin Resistance in Asymptomatic Patients with Acute Intermittent Porphyria and Liver-Targeted Insulin as a Novel Therapeutic Approach
Sign Up to like & getrecommendations! Published in 2021 at "Biomedicines"
DOI: 10.3390/biomedicines9030255
Abstract: Acute porphyria attacks are associated with the strong up-regulation of hepatic heme synthesis and over-production of neurotoxic heme precursors. First-line therapy is based on carbohydrate loading. However, altered glucose homeostasis could affect its efficacy. Our… read more here.
Keywords: insulin; liver targeted; targeted insulin; prevalence insulin ... See more keywords