Galactosylated chitosan coated liposomes of ledipasvir for liver targeting: Chemical synthesis, Statistical optimization, In-vitro and In-vivo evaluation.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2020.10.002
Abstract: Ledipasvir is a novel antiviral agent used in the treatment of hepatitis C. We aim in our study to increase its delivery to hepatocytes and prolong its retention within liver. Several formulae of ledipasvir loaded… read more here.
Keywords: liver targeting; chitosan coated; ledipasvir liver; galactosylated chitosan ... See more keywords
Toxicologic evaluations of recombinant liver‐targeting interferon IFN‐CSP: Genotoxicity and tegenicratoity
Sign Up to like & getrecommendations! Published in 2017 at "Regulatory Toxicology and Pharmacology"
DOI: 10.1016/j.yrtph.2017.07.003
Abstract: &NA; Interferon alpha as the one of FDA recommended drugs for Hepatitis B virus (HBV) infection has many side effects. Targeting IFN&agr; to the liver may be a strategy to increase its efficacy locally and… read more here.
Keywords: liver targeting; csp; interferon; ifn csp ... See more keywords
Use of a Liver-Targeting Immune-Tolerogenic mRNA Lipid Nanoparticle Platform to Treat Peanut-Induced Anaphylaxis by Single- and Multiple-Epitope Nucleotide Sequence Delivery.
Sign Up to like & getrecommendations! Published in 2023 at "ACS nano"
DOI: 10.1021/acsnano.2c12420
Abstract: While oral desensitization is capable of alleviating peanut allergen anaphylaxis, long-term immune tolerance is the sought-after goal. We developed a liver-targeting lipid nanoparticle (LNP) platform to deliver mRNA-encoded peanut allergen epitopes to liver sinusoidal endothelial… read more here.
Keywords: peanut allergen; peanut; liver targeting; lipid nanoparticle ... See more keywords
Improved Oral Bioavailability and Liver Targeting of Sorafenib Solid Lipid Nanoparticles in Rats
Sign Up to like & getrecommendations! Published in 2017 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-017-0901-3
Abstract: Minimal information is available on the oral bioavailability and liver-targeting properties of sorafenib solid lipid nanoparticles (SRF-SLNs) in rats. In this study, SRF-SLNs were prepared via the combined methods of high-speed shearing and ultrasonic treatment.… read more here.
Keywords: oral bioavailability; liver targeting; srf; bioavailability liver ... See more keywords
Liver Targeting Albumin-Coated Silybin-Phospholipid Particles Prepared by Nab™ Technology for Improving Treatment Effect of Acute Liver Damage in Intravenous Administration
Sign Up to like & getrecommendations! Published in 2019 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-019-1504-y
Abstract: In this study, a novel human serum albumin nanoparticle loading silybin-phospholipid complex (SLNPs) was developed for liver targeting after intravenous administration. The preparation of the drug delivery system consisted of two steps; initially, a silybin-phospholipid… read more here.
Keywords: silybin phospholipid; liver damage; liver targeting; acute liver ... See more keywords
Enhanced Liver Targeting of Camptothecin via Conjugation with Deoxycholic Acid
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24061179
Abstract: Camptothecin (CPT) shows potent anticancer activity through inhibition of topoisomerase I. However, its water insolubility and severe toxicity limit its clinical application. Coupling with bile acid moieties is a promising method for liver-targeted drug delivery,… read more here.
Keywords: liver targeting; cpt; camptothecin; deoxycholic acid ... See more keywords