Galactosylated chitosan coated liposomes of ledipasvir for liver targeting: Chemical synthesis, Statistical optimization, In-vitro and In-vivo evaluation.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2020.10.002
Abstract: Ledipasvir is a novel antiviral agent used in the treatment of hepatitis C. We aim in our study to increase its delivery to hepatocytes and prolong its retention within liver. Several formulae of ledipasvir loaded… read more here.
Keywords: liver targeting; chitosan coated; ledipasvir liver; galactosylated chitosan ... See more keywords
Toxicologic evaluations of recombinant liver‐targeting interferon IFN‐CSP: Genotoxicity and tegenicratoity
Sign Up to like & getrecommendations! Published in 2017 at "Regulatory Toxicology and Pharmacology"
DOI: 10.1016/j.yrtph.2017.07.003
Abstract: &NA; Interferon alpha as the one of FDA recommended drugs for Hepatitis B virus (HBV) infection has many side effects. Targeting IFN&agr; to the liver may be a strategy to increase its efficacy locally and… read more here.
Keywords: liver targeting; csp; interferon; ifn csp ... See more keywords
The Pharmacokinetics and Liver-Targeting Evaluation of Silybin Liposomes Mediated by the NTCP/OCTN2 Dual Receptors.
Sign Up to like & getrecommendations! Published in 2024 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.3c01245
Abstract: The disadvantage of a traditional dosage regimen is the inability to deliver a sufficient drug concentration to the lesion site, which can result in adverse side effects due to nonspecific drug delivery. Actively targeting hepatic… read more here.
Keywords: targeting evaluation; liver targeting; drug; evaluation silybin ... See more keywords
Use of a Liver-Targeting Immune-Tolerogenic mRNA Lipid Nanoparticle Platform to Treat Peanut-Induced Anaphylaxis by Single- and Multiple-Epitope Nucleotide Sequence Delivery.
Sign Up to like & getrecommendations! Published in 2023 at "ACS nano"
DOI: 10.1021/acsnano.2c12420
Abstract: While oral desensitization is capable of alleviating peanut allergen anaphylaxis, long-term immune tolerance is the sought-after goal. We developed a liver-targeting lipid nanoparticle (LNP) platform to deliver mRNA-encoded peanut allergen epitopes to liver sinusoidal endothelial… read more here.
Keywords: peanut allergen; peanut; liver targeting; lipid nanoparticle ... See more keywords
Paeoniflorin loaded liposomes modified with glycyrrhetinic acid for liver-targeting: preparation, characterization, and pharmacokinetic study
Sign Up to like & getrecommendations! Published in 2024 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2024.2319738
Abstract: Abstract Objective To enhance the retention times and therapeutic efficacy of paeoniflorin (PF), a liver-targeted drug delivery system has been developed using glycyrrhetinic acid (GA) as a ligand. Significance The development and optimization of GA-modified… read more here.
Keywords: glycyrrhetinic acid; liver targeting; study; paeoniflorin ... See more keywords
Improved Oral Bioavailability and Liver Targeting of Sorafenib Solid Lipid Nanoparticles in Rats
Sign Up to like & getrecommendations! Published in 2017 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-017-0901-3
Abstract: Minimal information is available on the oral bioavailability and liver-targeting properties of sorafenib solid lipid nanoparticles (SRF-SLNs) in rats. In this study, SRF-SLNs were prepared via the combined methods of high-speed shearing and ultrasonic treatment.… read more here.
Keywords: oral bioavailability; liver targeting; srf; bioavailability liver ... See more keywords
Liver Targeting Albumin-Coated Silybin-Phospholipid Particles Prepared by Nab™ Technology for Improving Treatment Effect of Acute Liver Damage in Intravenous Administration
Sign Up to like & getrecommendations! Published in 2019 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-019-1504-y
Abstract: In this study, a novel human serum albumin nanoparticle loading silybin-phospholipid complex (SLNPs) was developed for liver targeting after intravenous administration. The preparation of the drug delivery system consisted of two steps; initially, a silybin-phospholipid… read more here.
Keywords: silybin phospholipid; liver damage; liver targeting; acute liver ... See more keywords
Nanoparticle technologies for liver targeting and their applications in liver diseases
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2025.1661872
Abstract: Liver diseases represent a significant global health challenge, affecting millions of lives annually. The advent of nanoparticle (NP) technologies has introduced promising therapeutic strategies for addressing liver diseases. Given the liver’s pivotal role in detoxification… read more here.
Keywords: targeting applications; liver diseases; liver targeting; nanoparticle technologies ... See more keywords
Development of Liver-Targeting αVβ5+ Exosomes as Anti-TGF-β Nanocarriers for the Treatment of the Pre-Metastatic Niche
Sign Up to like & getrecommendations! Published in 2024 at "Biology"
DOI: 10.3390/biology13121066
Abstract: Simple Summary Exosomes are small vesicles released by our cells to communicate. Tumor cells also release exosomes that can go to the liver when they have the integrin αVβ5, an adhesion receptor, on their surface.… read more here.
Keywords: pre metastatic; liver targeting; metastatic niche; development liver ... See more keywords
Enhanced Liver Targeting of Camptothecin via Conjugation with Deoxycholic Acid
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24061179
Abstract: Camptothecin (CPT) shows potent anticancer activity through inhibition of topoisomerase I. However, its water insolubility and severe toxicity limit its clinical application. Coupling with bile acid moieties is a promising method for liver-targeted drug delivery,… read more here.
Keywords: liver targeting; cpt; camptothecin; deoxycholic acid ... See more keywords