Machine Learning Models for Predicting Liver Toxicity.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1960-5_15
Abstract: Liver toxicity is a major adverse drug reaction that accounts for drug failure in clinical trials and withdrawal from the market. Therefore, predicting potential liver toxicity at an early stage in drug discovery is crucial… read more here.
Keywords: learning models; drug; toxicity; liver toxicity ... See more keywords
Role of peroxisome proliferator-activated receptor alpha (PPARα) and PPARα-mediated species differences in triclosan-induced liver toxicity
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Toxicology"
DOI: 10.1007/s00204-018-2308-7
Abstract: Triclosan, a widely used broad spectrum anti-bacterial agent, is hepatotoxic in rodents and exhibits differential effects on mouse and human peroxisome proliferator-activated receptor alpha (PPARα) in vitro; however, the mechanism underlying triclosan-induced liver toxicity has… read more here.
Keywords: ppar; liver toxicity; triclosan induced; role ... See more keywords
Maternal exposure to perfluorooctanoic acid (PFOA) causes liver toxicity through PPAR-α pathway and lowered histone acetylation in female offspring mice
Sign Up to like & getrecommendations! Published in 2019 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-019-05258-z
Abstract: The study was conducted to investigate the liver toxicity in female offspring mice induced by maternal exposure to perfluorooctanoic acid (PFOA). Fifty pregnant Kunming mice were randomly divided into 5 groups with 10 of each,… read more here.
Keywords: liver toxicity; pfoa; offspring mice; maternal exposure ... See more keywords
The role of inflammasome activation in Triptolide-induced acute liver toxicity.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.105754
Abstract: Triptolide (TP), the major active compound derived from the traditional Chinese medicine Tripterygium wilfordii Hook. F, possesses an excellent pharmacological profile of immunomodulatory and anti-tumor activities. However, the application of TP was restricted due to… read more here.
Keywords: acute liver; inflammasome; liver toxicity; activation ... See more keywords
Protective effects of salep against isoniazid liver toxicity in wistar rats
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Traditional and Complementary Medicine"
DOI: 10.1016/j.jtcme.2017.06.001
Abstract: Introduction Isoniazid is a drug for treatment of tuberculosis. One of the main side effects of this drug is hepatotoxicity, which is a major cause of treatment interruption in tuberculosis. This study is about the… read more here.
Keywords: isoniazid; liver toxicity; salep; group ... See more keywords
Mechanisms involved in the possible protective effect of chrysin against sodium arsenite-induced liver toxicity in rats.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118965
Abstract: Arsenic as a one of the most important toxic metals could induce hepatotoxicity. Previous reports revealed the significance of oxidative stress in promoting of arsenic-induced liver toxicity. The aim of the present investigation is to… read more here.
Keywords: liver toxicity; effect chrysin; sodium arsenite; induced liver ... See more keywords
Mechanistic identification of biofluid metabolite changes as markers of acetaminophen‐induced liver toxicity in rats
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2019.04.001
Abstract: &NA; Acetaminophen (APAP) is the most commonly used analgesic and antipyretic drug in the world. Yet, it poses a major risk of liver injury when taken in excess of the therapeutic dose. Current clinical markers… read more here.
Keywords: induced liver; metabolism; liver toxicity; liver injury ... See more keywords
Strategies for prediction and mitigation of radiation-induced liver toxicity
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Radiation Research"
DOI: 10.1093/jrr/rrx104
Abstract: Abstract Although well described in the 1960s, liver toxicity secondary to radiation therapy, commonly known as radiation-induced liver disease (RILD), remains a major challenge. RILD encompasses two distinct clinical entities, a ‘classic’ form, composed of… read more here.
Keywords: liver toxicity; radiation induced; toxicity; induced liver ... See more keywords
Polystyrene nanoplastics exacerbated Pb-induced liver toxicity in mice
Sign Up to like & getrecommendations! Published in 2023 at "Toxicology Research"
DOI: 10.1093/toxres/tfad031
Abstract: Nanoplastics are widely distributed in the environment and can adsorb heavy metals, which poses a potential threat to human health through food chain. It is necessary to assess the combined toxicity of nanoplastics and heavy… read more here.
Keywords: liver toxicity; toxicity; polystyrene nanoplastics; group ... See more keywords
Antioxidant traits and protective impact of Moringa oleifera leaf extract against diclofenac sodium-induced liver toxicity in rats.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of food biochemistry"
DOI: 10.1111/jfbc.12704
Abstract: Moringa oleifera gained importance as a medicinal plant. The current study assesses Moringa leaf ethanol extracts (MLE) against experimentally diclofenac sodium (DcNa)-induced liver toxicity in male rats. Leaves were extracted with different solvents differing in… read more here.
Keywords: moringa oleifera; diclofenac sodium; liver toxicity; induced liver ... See more keywords
Imatinib and liver toxicity
Sign Up to like & getrecommendations! Published in 2018 at "BMJ Case Reports"
DOI: 10.1136/bcr-2018-226740
Abstract: Imatinib is a specific tyrosine kinase inhibitor which has been approved for the treatment of Philadelphia chromosome-positive chronic myeloid leukaemia and c-KIT (CD117)-positive gastrointestinal stromal tumours. It has been associated with hepatotoxicity ranging from abnormal… read more here.
Keywords: liver function; liver toxicity; liver; imatinib liver ... See more keywords